For laboratories dedicated to peptide synthesis, having access to high-quality reagents is non-negotiable. Fmoc-L-Arg(Pbf)-OH (CAS 154445-77-9) is a critical amino acid derivative essential for incorporating arginine into peptide chains using the Fmoc Solid Phase Peptide Synthesis (SPPS) method. This derivative’s specific protection strategy is key to avoiding side reactions and ensuring the integrity of complex peptide sequences.

As a leading supplier and manufacturer, we understand the daily demands of peptide synthesis labs. Our commitment is to provide Fmoc-L-Arg(Pbf)-OH that meets the highest standards of purity and consistency. If you are looking to buy Fmoc-L-Arg(Pbf)-OH, this guide will highlight why our product and service are the right choice for your lab.

The Chemistry Behind Fmoc-L-Arg(Pbf)-OH

Arginine's guanidino side chain is notoriously reactive. Without proper protection, it can lead to issues like side-chain acylation or alkylation during the repetitive coupling and deprotection cycles of SPPS. Fmoc-L-Arg(Pbf)-OH solves this problem by incorporating two crucial protecting groups:

  • Fmoc Group: Protects the alpha-amino group, easily removed by piperidine in DMF during each coupling step. This allows the linear extension of the peptide chain.
  • Pbf Group (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl): This group effectively shields the guanidino side chain. It remains stable during the basic deprotection of the Fmoc group but is conveniently removed under acidic conditions (e.g., TFA) during the final cleavage from the resin. This strategic protection minimizes side reactions and ensures the fidelity of the synthesized peptide.

Why Choose Us as Your Supplier?

Laboratories require reliability, purity, and value. When you purchase Fmoc-L-Arg(Pbf)-OH from us, you receive:

  • Exceptional Purity: Our Fmoc-L-Arg(Pbf)-OH is guaranteed to be ≥99.0% pure, ensuring that your synthesis reactions proceed smoothly and your resulting peptides are of the highest quality, critical for research reproducibility.
  • Consistent Quality: We maintain rigorous quality control measures to ensure batch-to-batch consistency, which is vital for labs that perform ongoing synthesis projects or scale-up reactions.
  • Competitive Pricing: We offer attractive prices for Fmoc-L-Arg(Pbf)-OH, especially for bulk orders. This allows research labs to manage their budgets effectively without compromising on reagent quality.
  • Reliable Supply: As an established manufacturer and supplier, we maintain robust inventory levels to ensure timely delivery, so your synthesis projects are never delayed due to reagent shortages.

Applications in Peptide Synthesis Labs

Fmoc-L-Arg(Pbf)-OH is a workhorse reagent for:

  • Research Peptide Synthesis: Creating peptides for biological assays, structural studies, and exploring peptide-protein interactions.
  • Custom Peptide Synthesis Services: Essential for companies offering custom peptide synthesis to clients in academia and industry.
  • Drug Discovery: Building peptide libraries and lead compounds in early-stage drug discovery efforts.

We are dedicated to supporting the peptide synthesis community by providing premium reagents. We encourage you to contact us for a quote on Fmoc-L-Arg(Pbf)-OH and to discuss how we can meet your lab's supply needs. Partner with a trusted manufacturer for your critical peptide synthesis reagents.