For those in the pharmaceutical and biotechnology industries engaged in peptide synthesis, understanding the intricate details of the reagents used is key to success. Fmoc-L-Arg(Pbf)-OH (CAS 154445-77-9) is one such critical reagent, fundamental for the accurate and efficient incorporation of arginine into peptide sequences, particularly within the prevalent Fmoc Solid Phase Peptide Synthesis (SPPS) methodology.

As a dedicated supplier and manufacturer, we provide high-quality Fmoc-L-Arg(Pbf)-OH, ensuring that researchers and production teams have access to the best materials. If you are looking to buy Fmoc-L-Arg(Pbf)-OH, understanding its scientific underpinnings will highlight its value and necessity.

Chemical Structure and Protective Group Strategy

Fmoc-L-Arg(Pbf)-OH is a derivative of the amino acid L-arginine. Its structure is optimized for SPPS through the strategic use of protecting groups:

  • Fmoc (9-fluorenylmethyloxycarbonyl): This group protects the alpha-amino group of the arginine residue. It is labile under basic conditions, such as treatment with piperidine, allowing for the sequential addition of amino acids during peptide chain elongation.
  • Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl): This bulky group is attached to the guanidino side chain of arginine. The guanidino group is highly basic and nucleophilic, and without protection, it can lead to significant side reactions. The Pbf group effectively shields this reactive moiety. Importantly, it is stable to the basic conditions used for Fmoc deprotection but can be efficiently removed under acidic conditions, typically in the final cleavage cocktail (e.g., using TFA).

Performance and Application Advantages

The careful design of Fmoc-L-Arg(Pbf)-OH provides several key advantages for peptide synthesis:

  • High Yields and Purity: By effectively preventing side reactions involving the arginine side chain, this derivative significantly improves the yield and purity of the synthesized peptide. This makes it an excellent choice when you purchase for critical projects.
  • Compatibility with Fmoc SPPS: It is fully compatible with standard Fmoc SPPS protocols, including automated synthesis, ensuring seamless integration into existing workflows.
  • Reliability: As a leading supplier, we ensure our Fmoc-L-Arg(Pbf)-OH meets stringent quality standards (≥99.0% purity), providing researchers and manufacturers with a reliable and consistent product for their synthesis needs.
  • Competitive Pricing: We offer competitive prices for high-quality Fmoc-L-Arg(Pbf)-OH, especially for bulk orders, making advanced peptide synthesis more accessible.

Key Applications

Fmoc-L-Arg(Pbf)-OH is indispensable for:

  • Pharmaceutical Peptide Synthesis: Critical for manufacturing peptide-based drugs and drug candidates where arginine plays a vital role in biological activity.
  • Research & Development: Used extensively in academic and industrial labs for synthesizing peptides for drug discovery, structural studies, and biochemical assays.
  • Custom Peptide Synthesis: A fundamental reagent for CROs and custom synthesis providers.

We are committed to being a top-tier manufacturer and supplier of specialty chemicals. We encourage you to contact us for a quote on Fmoc-L-Arg(Pbf)-OH and to learn more about our comprehensive range of peptide synthesis reagents.