In the competitive landscape of biochemical research and pharmaceutical development, the quality and specificity of chemical reagents are paramount. For those engaged in the complex synthesis of peptides, especially for therapeutic or diagnostic purposes, advanced building blocks are indispensable. Fmoc-Asp(OtBu)-OH (13C4,15N), identified by its CAS number 1217468-27-3, stands as a critical example of such a vital component, offering enhanced precision and analytical capabilities.

This particular derivative of aspartic acid is notable for its incorporation of stable isotopes, specifically carbon-13 (four atoms) and nitrogen-15 (one atom). This deliberate isotopic labeling transforms the molecule into a powerful tool for quantitative analysis, particularly within mass spectrometry-based applications. Researchers and procurement managers are increasingly seeking out these specialized compounds to ensure the accuracy and reproducibility of their experimental results.

The primary application domain for Fmoc-Asp(OtBu)-OH (13C4,15N) is in the realm of Fmoc Solid-Phase Peptide Synthesis (SPPS). When this labeled aspartic acid is incorporated into a growing peptide chain, it functions as an internal standard. This internal standard enables highly accurate and sensitive quantification of the target peptide, even when dealing with complex biological matrices or low analyte concentrations. This is a crucial advantage for pharmaceutical companies involved in drug discovery and development, where precise measurement of peptide drug levels is vital for pharmacokinetic and pharmacodynamic studies.

For organizations looking to buy Fmoc-Asp(OtBu)-OH (13C4,15N), partnering with a reliable manufacturer is essential. Many leading suppliers, including those in China known for their expertise in fine chemical synthesis, offer this high-purity labeled amino acid. By sourcing from such trusted manufacturers, you can ensure consistent isotopic enrichment and chemical purity, which are critical for obtaining reliable analytical data. The competitive pricing often available further supports the economic viability of using these advanced reagents.

Moreover, the use of Fmoc-Asp(OtBu)-OH (13C4,15N) extends to metabolic tracing studies. The stable isotopes allow researchers to track the incorporation and metabolic fate of the labeled aspartic acid residue within biological systems. This provides invaluable insights into peptide synthesis, processing, and degradation pathways, which are fundamental for understanding cellular functions and optimizing therapeutic strategies.

In conclusion, Fmoc-Asp(OtBu)-OH (13C4,15N) is a sophisticated and indispensable chemical intermediate for advanced peptide synthesis and analysis. Its precise isotopic labeling provides the accuracy necessary for critical research applications, from quantitative drug analysis to intricate metabolic studies. Ensuring a stable supply of this high-quality reagent from a reputable manufacturer is a key step for any organization committed to innovation in peptide science and pharmaceutical development.