The synthesis of complex peptides is a cornerstone of modern biological and pharmaceutical research. As scientists endeavor to create novel peptides for therapeutic, diagnostic, or research purposes, the quality and precision of the building blocks they use become critically important. Fmoc-Asp(OtBu)-OH (13C4,15N), with its CAS number 1217468-27-3, exemplifies a highly valuable reagent that significantly elevates the standards of peptide synthesis.

This specialized amino acid derivative is characterized by its incorporation of stable isotopes, specifically carbon-13 (four atoms) and nitrogen-15 (one atom) into its structure. This isotopic labeling imbues the molecule with unique properties that are leveraged extensively in advanced analytical techniques, particularly those involving mass spectrometry. For researchers and procurement specialists, understanding how to procure and utilize such compounds effectively is key to unlocking their full potential.

The primary application of Fmoc-Asp(OtBu)-OH (13C4,15N) is within the widely adopted Fmoc Solid-Phase Peptide Synthesis (SPPS) methodology. When this labeled aspartic acid derivative is coupled onto a growing peptide chain, it acts as a built-in internal standard. This internal standard allows for highly accurate and sensitive quantification of the synthesized peptide in complex biological samples. This is an indispensable requirement for many areas of research, including pharmacokinetics, pharmacodynamics, and biomarker discovery, where precise measurement of peptide levels is essential.

By purchasing this specialized reagent from a reputable manufacturer, such as those found in China known for their expertise in fine chemical production, researchers can ensure the isotopic purity and overall quality necessary for reliable results. The ability to precisely track and quantify peptides is fundamental to validating drug candidates and understanding their behavior within biological systems.

Beyond quantitative analysis, the use of isotopically labeled amino acids like Fmoc-Asp(OtBu)-OH (13C4,15N) also opens avenues for metabolic studies. Researchers can trace the incorporation and fate of the labeled amino acid within cellular processes, providing deeper insights into protein synthesis and turnover. This level of detail is often crucial for understanding disease mechanisms and developing targeted therapies.

The growing demand for such advanced chemical intermediates highlights the importance of a robust supply chain. Manufacturers specializing in labeled compounds play a critical role in supporting the scientific community. When you are looking to buy Fmoc-Asp(OtBu)-OH (13C4,15N), partnering with a supplier that emphasizes quality control and offers competitive pricing ensures that your research projects can proceed without interruption.

In essence, Fmoc-Asp(OtBu)-OH (13C4,15N) is more than just a building block; it is an enabler of advanced analytical capabilities in peptide synthesis. Its precise isotopic labeling provides the accuracy needed for critical research and development activities, from early-stage drug discovery to detailed biological pathway analysis. For any laboratory engaged in cutting-edge peptide science, ensuring access to high-quality labeled reagents like this is a strategic advantage.