In the realm of modern organic chemistry and biochemistry, specialized amino acids play a pivotal role in advancing scientific frontiers. Fmoc-D-3-Methylphenylalanine (CAS 352351-64-5) stands out as a particularly versatile compound, widely utilized as a building block in sophisticated peptide synthesis protocols. Its unique structural features, including the Fmoc protecting group and a meta-methyl substitution on the phenylalanine side chain, equip it for a range of critical applications.

The foundation of Fmoc-D-3-Methylphenylalanine's utility lies in its role in peptide synthesis. The Fmoc group is a cornerstone of the widely adopted Fmoc solid-phase peptide synthesis (SPPS) strategy. This strategy relies on the sequential addition of amino acids, each protected at the N-terminus by the Fmoc group. The Fmoc group is readily cleaved under mild basic conditions, typically using piperidine, allowing for the next amino acid to be coupled without damaging the growing peptide chain or the resin. This process is vital for creating peptides with high purity and defined sequences, essential for both research and therapeutic applications. The ‘D’ designation indicates the specific stereochemistry, important for creating non-natural peptides with modified biological activities or stability.

The distinctive feature of Fmoc-D-3-Methylphenylalanine is the methyl group positioned at the meta-carbon of the phenyl ring in the phenylalanine side chain. This seemingly small alteration can have profound effects on the resulting peptide’s properties. It can influence factors such as peptide conformation, hydrophobicity, and interactions with biological targets. Researchers leverage this modification to fine-tune peptide characteristics, making it an invaluable tool for structure-activity relationship (SAR) studies. By systematically altering peptide sequences with modified amino acids like this one, scientists can optimize binding affinity, improve bioavailability, or enhance receptor selectivity in drug discovery programs.

The compound's status as a specialty chemical means it is crucial for researchers and manufacturers to source it from reliable providers. Many chemical suppliers, particularly those with strong networks in China, offer Fmoc-D-3-Methylphenylalanine in high-purity grades, often exceeding 97% as determined by HPLC analysis. When considering to buy this reagent, understanding its CAS number, 352351-64-5, is essential for accurate identification. The purity and consistency of this building block directly impact the success of complex synthesis projects, making the selection of a trusted supplier a critical decision.

Beyond its primary use in peptide synthesis, Fmoc-D-3-Methylphenylalanine finds application in various areas of organic synthesis and biochemical research. It can be incorporated into peptide libraries for screening potential drug candidates or used to create peptides with tailored properties for diagnostic assays. Its availability as a research chemical supports innovation across multiple scientific disciplines, from medicinal chemistry to materials science, where precisely engineered peptides are increasingly in demand.

In conclusion, Fmoc-D-3-Methylphenylalanine represents a powerful and versatile amino acid derivative that significantly contributes to advancements in peptide chemistry and related fields. Its specific structural features, combined with the robustness of Fmoc chemistry, make it an indispensable tool for scientists seeking to design and synthesize peptides with precise characteristics and functions.