The synthesis of complex peptides is a cornerstone of modern biological and pharmaceutical research. Among the myriad of chemical building blocks available, Fmoc-D-3-Methylphenylalanine (CAS 352351-64-5) has emerged as a particularly valuable specialty amino acid. Its unique structure, featuring an Fmoc-protected amine and a methyl-substituted phenylalanine side chain, makes it an indispensable tool for researchers engaged in cutting-edge peptide synthesis and drug discovery efforts.

The primary utility of Fmoc-D-3-Methylphenylalanine lies in its application within solid-phase peptide synthesis (SPPS). The Fmoc protecting group is a linchpin in this methodology, allowing for sequential addition of amino acids to a growing peptide chain. Its orthogonal removal under basic conditions, typically using piperidine, ensures that other sensitive functional groups within the peptide remain intact. This orthogonality is crucial for building peptides with high fidelity and yield, especially for longer or more complex sequences. The ‘D’ designation signifies the specific stereochemistry, differentiating it from its L-enantiomer and opening up possibilities for exploring non-natural peptide structures that can offer enhanced stability or novel biological activities.

The presence of the methyl group at the meta-position of the phenyl ring in Fmoc-D-3-Methylphenylalanine is a key feature that researchers leverage. This subtle structural modification can lead to significant changes in the conformational landscape and binding properties of the final peptide. By subtly altering the steric bulk and electronic distribution of the side chain, this methyl group can influence how the peptide interacts with its biological targets, such as proteins or cell receptors. This makes it an excellent choice for structure-activity relationship (SAR) studies, a critical phase in drug development where chemists systematically modify molecular structures to optimize efficacy and safety. When considering the purchase of this compound, understanding these benefits is crucial for selecting the right materials for your research goals.

As a specialty chemical, Fmoc-D-3-Methylphenylalanine is readily available from a global network of suppliers, including many prominent chemical manufacturers and distributors based in China. These suppliers often guarantee high purity levels, typically exceeding 97% (as confirmed by HPLC), which is essential for reproducible and reliable experimental outcomes. For scientists aiming to buy this crucial reagent, selecting a supplier known for quality control and consistent product availability is paramount. The CAS number, 352351-64-5, serves as a universal identifier, simplifying the procurement process across various platforms.

The applications of Fmoc-D-3-Methylphenylalanine are diverse, ranging from the synthesis of therapeutic peptides to the development of biochemical tools for investigating protein function. Its inclusion in custom peptide synthesis projects allows for the creation of peptides with unique properties, such as increased metabolic stability or altered receptor binding affinities. This versatility makes it a valuable asset for researchers in fields such as medicinal chemistry, biochemistry, and molecular biology. The ongoing quest for novel peptide-based drugs and diagnostics fuels the demand for high-quality, specialized amino acid derivatives like this one.

In essence, Fmoc-D-3-Methylphenylalanine represents a powerful tool for peptide chemists. Its contribution to the precise and efficient synthesis of peptides, coupled with the structural insights provided by its unique side chain, solidifies its position as a go-to specialty amino acid. By partnering with reliable suppliers, researchers can ensure they have access to the quality materials needed to drive innovation in peptide science and beyond.