In the rapidly evolving field of peptide synthesis, the quality and specificity of building blocks are paramount. Fmoc-D-Glu(OtBu)-OH, also known by its CAS number 104091-08-9, stands out as a critical N-alpha-Fmoc protected D-glutamic acid derivative. Its unique structure, featuring a tert-butyl ester protecting group on the gamma carboxyl, makes it an indispensable reagent for chemists aiming to construct complex peptide sequences with high fidelity.

The Fmoc (9-fluorenylmethyloxycarbonyl) group offers a base-labile protection strategy, which is orthogonal to acid-labile side-chain protecting groups commonly used in solid-phase peptide synthesis (SPPS). This orthogonality is fundamental for controlled deprotection and coupling cycles, ensuring that only the desired amino group is available for reaction at each step. For procurement managers and R&D scientists seeking to buy this crucial intermediate, understanding its role in the synthetic process is key to optimizing peptide production. When you purchase Fmoc-D-Glu(OtBu)-OH from a reputable manufacturer, you ensure the purity and reactivity necessary for successful SPPS.

The tert-butyl ester serves to protect the gamma-carboxyl group of glutamic acid. This protection is vital during the synthesis to prevent unwanted side reactions, such as cyclization or cross-linking, particularly when the glutamic acid residue is incorporated into a growing peptide chain. The stability of the tert-butyl ester under standard Fmoc deprotection conditions (using piperidine) and its subsequent cleavage under stronger acidic conditions (like TFA) make it a versatile choice. Researchers looking for a dependable supplier of Fmoc-D-Glu(OtBu)-OH can find numerous options, but prioritizing those with stringent quality control is essential for consistent outcomes.

The demand for high-quality amino acid derivatives like Fmoc-D-Glu(OtBu)-OH continues to grow as peptide-based therapeutics and diagnostics gain prominence. Whether you are involved in academic research or large-scale pharmaceutical manufacturing, securing a stable supply of this reagent is crucial. Many manufacturers in China specialize in producing these advanced intermediates, offering competitive pricing without compromising on quality. Investigating the price and availability from various suppliers will help in optimizing your procurement strategy.

For scientists and procurement professionals aiming to purchase Fmoc-D-Glu(OtBu)-OH, seeking products with documented high purity (e.g., ≥98.0% by HPLC) is a standard practice. This ensures the integrity of the final peptide product. Exploring the long-term supply capabilities of potential partners is also advisable, especially for projects that require significant quantities of this specialized amino acid derivative.