Fmoc-D-Glu(OtBu)-OH (CAS 104091-08-9), chemically known as N-alpha-(9-Fluorenylmethyloxycarbonyl)-D-glutamic acid gamma-tert-butyl ester, is a highly specialized amino acid derivative. Its unique combination of protecting groups and stereochemistry makes it invaluable for targeted applications in biochemistry, organic synthesis, and pharmaceutical development. For professionals seeking to buy this compound, a clear understanding of its properties is crucial.

The molecule's structure features a D-glutamic acid backbone, which is a less common enantiomer than L-glutamic acid but is often required for specific biological activities or peptide sequences. The N-terminal amine is protected by the Fmoc group, a widely adopted strategy in Solid-Phase Peptide Synthesis (SPPS) due to its mild deprotection conditions. The gamma-carboxyl group is protected as a tert-butyl ester, providing stability during synthesis and allowing for selective cleavage later in the process. This dual protection ensures controlled reactivity and prevents unwanted side reactions.

Key properties of Fmoc-D-Glu(OtBu)-OH include its typical appearance as a white to off-white crystalline powder and its solubility in polar organic solvents such as DMSO, DMF, and dichloromethane. Its melting point generally falls within the range of 80-100 °C, though variations can occur based on purity and hydration state. When sourcing from a manufacturer, it's important to note the specified purity levels, often determined by HPLC, and the enantiomeric purity, confirmed by chiral chromatography or optical rotation measurements.

The applications of Fmoc-D-Glu(OtBu)-OH are broad. It is a staple in the synthesis of peptides containing D-glutamic acid, which can confer altered proteolytic stability or receptor binding properties compared to their L-counterparts. In pharmaceutical research, it serves as a building block for peptidomimetics, drug conjugates, and small molecule therapeutics, especially those designed to interact with neurological pathways. Researchers often look to suppliers who can provide consistent quality and readily available documentation.

When procuring this specialized chemical, understanding the price structure and availability from various suppliers, including those in China, is essential for managing research budgets and project timelines. A careful selection of a reputable supplier ensures that you receive a high-quality product that meets your rigorous synthetic requirements.