In the dynamic landscape of pharmaceutical research and manufacturing, securing high-quality chemical intermediates is foundational to the successful development of new drugs. For those working with advanced oncology treatments, 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, known by its CAS number 1256584-80-1, represents a critical building block. This sophisticated organic compound is essential for the synthesis of potent Anaplastic Lymphoma Kinase (ALK) inhibitors, such as Alectinib, which are pivotal in treating specific forms of cancer. This guide aims to assist procurement managers and R&D scientists in understanding the specifications and best practices for purchasing this vital intermediate.

Key Product Specifications and Quality Assurance

When sourcing 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, paying close attention to its specifications is paramount. The compound is typically presented as a white powder and boasts a high purity level, commonly 98%. Its molecular formula is C21H17IN2O, with a molecular weight around 440.28 g/mol. The CAS registry number 1256584-80-1 ensures unambiguous identification. For any commercial transaction, a comprehensive Certificate of Analysis (CoA) is indispensable. This document provides empirical data on the product's purity, identifies any impurities, and confirms its physical and chemical properties. Reliable manufacturers will also provide Safety Data Sheets (SDS) to ensure safe handling and regulatory compliance. Verifying these documents before making a purchase is a critical step in ensuring the intermediate will perform as expected in your synthesis processes.

Finding Reliable China Manufacturers and Suppliers

The global market for specialized chemical intermediates is competitive, with many manufacturers located in China offering strong production capabilities and cost-effectiveness. When looking to buy CAS 1256584-80-1, consider the following attributes in a potential supplier:

  • Manufacturing Experience: Proven expertise in complex organic synthesis and pharmaceutical intermediates.
  • Quality Systems: Adherence to international quality standards, such as ISO certification.
  • Production Capacity: Ability to scale production from laboratory quantities to commercial volumes.
  • Customer Support: Responsive communication, technical assistance, and transparent pricing.
  • Logistics: Clear terms for payment (L/C, T/T, PayPal), shipping (FOB, CIF), and timely delivery.

Establishing a direct relationship with manufacturers allows for better negotiation on price for bulk purchases and provides direct access to technical support. Many reputable chemical manufacturers also offer custom synthesis services, which can be invaluable if your project requires modifications or specific purity profiles.

Strategic Purchasing for Drug Development

The demand for 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile is directly linked to the advancements in targeted cancer therapies. As the pharmaceutical industry continues to innovate, the need for reliable suppliers of such critical intermediates will only increase. Procurement professionals should proactively identify and qualify manufacturers who can guarantee a consistent supply, thereby securing their own production pipelines. By focusing on quality, reliability, and competitive pricing when you buy this essential compound, you can significantly enhance the efficiency and success rate of your pharmaceutical development projects.