In the pharmaceutical industry, the efficiency and integrity of the supply chain are critical for delivering life-saving medications. 1-Methylindole, identified by CAS number 603-76-9, is a key chemical intermediate whose consistent quality and availability are essential for the production of vital APIs. This article explores the properties, applications, and procurement considerations for 1-Methylindole, particularly its role in the synthesis of Osimertinib.

Understanding 1-Methylindole: Properties and Specifications

1-Methylindole is a transparent brown liquid chemical with a molecular formula of C9H9N and a molecular weight of 131.174. A crucial specification for its use in pharmaceutical manufacturing is its high purity, with an assay of ≥98.0%. This ensures that the compound can be effectively utilized in complex synthesis pathways without introducing unwanted impurities that could compromise the final API. Standard packaging typically involves 200 kg drums, and it requires storage in a cool, well-ventilated area to maintain its chemical integrity.

The Critical Link to Osimertinib Production

The significance of 1-Methylindole in the pharmaceutical sector is profoundly linked to its role as a precursor intermediate in the synthesis of Osimertinib. Osimertinib is a highly effective targeted therapy for specific types of non-small cell lung cancer (NSCLC), and its production relies heavily on the availability of precisely manufactured intermediates like 1-Methylindole. Pharmaceutical companies looking to manufacture Osimertinib must therefore secure reliable sources for this compound to ensure consistent production and meet patient demand. Beyond this specific application, the indole chemical structure of 1-Methylindole also makes it a valuable component for other research and development activities in medicinal chemistry.

Procurement Best Practices for 1-Methylindole

For any organization looking to buy 1-Methylindole, a structured procurement process is vital:

  • Supplier Selection: Identifying and qualifying manufacturers and suppliers is the primary step. Companies often look to global suppliers, including those in China, known for their chemical manufacturing capabilities and competitive pricing.
  • Quality Assurance: It is imperative to obtain a Certificate of Analysis (CoA) to verify that the 1-Methylindole meets the required specifications, particularly the ≥98.0% purity and correct CAS number (603-76-9). Understanding the supplier's quality management systems is also beneficial.
  • Price and Value: Requesting price quotations from several suppliers allows for a comparison of costs. However, value should be assessed holistically, considering not just the price but also the product quality, consistency, and supplier reliability.
  • Logistics and Support: Confirm that the supplier can meet delivery timelines and provide adequate packaging and any necessary technical or regulatory support.

Conclusion

1-Methylindole (CAS 603-76-9) is a fundamental intermediate in the pharmaceutical supply chain, critical for the production of advanced therapies like Osimertinib. By adopting best practices in procurement, focusing on quality and supplier reliability, companies can ensure they have access to this essential chemical, supporting advancements in patient care.