In the exacting field of pharmaceutical manufacturing, the purity of starting materials and intermediates directly correlates with the safety, efficacy, and consistency of the final drug product. 6-Chlorouracil (CAS 4270-27-3) is one such crucial intermediate, and its purity level, typically specified at 99%, is non-negotiable for most applications.

Understanding Purity Standards for 6-Chlorouracil

6-Chlorouracil, with its molecular formula C4H3ClN2O2 and molecular weight of 146.53 g/mol, is a heterocyclic organic compound. While it may appear as a simple white to off-white crystalline powder, its precise chemical composition is vital. A 99% assay signifies that 99% of the material consists of the intended 6-Chlorouracil molecule, with only 1% comprising impurities. These impurities can be residual solvents, by-products from synthesis, or degradation products. In pharmaceutical synthesis, even trace amounts of certain impurities can lead to unwanted side reactions, reduced yields, or the formation of potentially harmful contaminants in the final API.

Why 99% Purity is Critical for Pharmaceuticals

  • Reaction Efficiency: High purity ensures that the intended reactions proceed as expected, leading to optimal yields of the desired product, such as alogliptin.
  • API Quality: Impurities in intermediates can carry through the synthesis process, compromising the quality and safety of the final drug. Regulatory bodies demand stringent impurity control.
  • Process Reproducibility: Consistent purity ensures that manufacturing processes are reproducible batch after batch, which is essential for meeting Good Manufacturing Practice (GMP) standards.
  • Cost-Effectiveness: While higher purity materials might initially seem more expensive, they often prove more cost-effective by reducing rework, waste, and the risk of batch failure.

Where to Source High-Purity 6-Chlorouracil

For pharmaceutical companies looking to buy 6-chlorouracil, it is imperative to partner with reputable manufacturers and suppliers who can guarantee a 99% assay. When you decide to purchase 6-chlorouracil, always request the Certificate of Analysis (CoA) to verify the purity and impurity profile. Suppliers based in China, renowned for their robust chemical manufacturing sector, offer competitive pricing and large-scale production capabilities. Identifying a trustworthy 6-chlorouracil supplier that adheres to international quality standards is a critical step.

Ensuring the purity of your pharmaceutical intermediates is a fundamental aspect of quality assurance. We pride ourselves on being a reliable 6-chlorouracil manufacturer, committed to delivering products that meet the stringent requirements of the pharmaceutical industry. If you need to get a quote for 99% pure 6-Chlorouracil, our team is ready to assist you.