For researchers and formulators in the chemical and pharmaceutical industries, a thorough understanding of a compound's properties is fundamental to its successful application. 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, identified by CAS number 1215787-31-7, is a significant heterocyclic intermediate known for its utility in synthetic organic chemistry. This article explores its key chemical and physical properties, offering insights valuable to anyone looking to purchase or work with this compound, and highlights the importance of reliable sourcing from chemical manufacturers.

Chemical Structure and Identity: 6-Bromo-4-chloropyrido[2,3-d]pyrimidine possesses a fused bicyclic aromatic system, the pyrido[2,3-d]pyrimidine nucleus, substituted with a bromine atom at the 6-position and a chlorine atom at the 4-position. Its molecular formula is C7H3BrClN3, and its molecular weight is approximately 244.48 g/mol. This specific arrangement of atoms and functional groups dictates its reactivity and potential applications in synthesis. Accurate identification via its CAS number is essential when querying suppliers or searching databases.

Physical Characteristics: Typically, 6-Bromo-4-chloropyrido[2,3-d]pyrimidine presents as a solid. Sources often describe its appearance as a white to yellow crystalline solid. Its melting point is reported to be in the range of 152-154 °C, which is a key parameter for purity assessment and material handling. Understanding its physical state and melting point helps researchers anticipate how the material will behave in different conditions and during processing.

Synthesis and Purity: The synthesis of this compound commonly involves the conversion of a hydroxyl precursor into a chloride using chlorinating agents like POCl3. For instance, starting from 6-bromopyrido[2,3-d]pyrimidin-4(1H)-one, the reaction under reflux conditions, followed by purification, can yield 6-Bromo-4-chloropyrido[2,3-d]pyrimidine. The purity achieved, often reported around 95%, is critical for its use in sensitive reactions, particularly in pharmaceutical synthesis where impurities can significantly impact the outcome of subsequent steps or the final product's efficacy and safety. When you buy this chemical, always request the Certificate of Analysis (CoA) from the manufacturer to confirm purity and testing methods.

Reactivity and Applications: The bromine and chlorine atoms on the pyrido[2,3-d]pyrimidine ring are prime sites for further chemical transformations. The chlorine atom at the 4-position is particularly susceptible to nucleophilic aromatic substitution, allowing for the introduction of various amine, alkoxy, or thioalkoxy groups. The bromine at the 6-position can participate in palladium-catalyzed cross-coupling reactions, such as Suzuki, Stille, or Sonogashira couplings, enabling the formation of new carbon-carbon bonds. These reactions are fundamental in building complex molecular architectures for pharmaceutical research, agrochemicals, and material science. As a building block, its strategic placement of reactive handles makes it an attractive starting material for diverse synthetic projects.

Sourcing Reliable Suppliers: When you need to purchase 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, engaging with established chemical manufacturers and suppliers is crucial. Companies based in China often offer competitive pricing and a wide range of research chemicals. It's important to compare product specifications, pricing, and lead times from multiple sources. Many suppliers provide detailed product information, including synthesis references and analytical data, to support your purchasing decisions. Opting for a supplier that offers sample quantities can be beneficial for initial evaluation.

In summary, the chemical properties of 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, including its structure, physical characteristics, and reactivity, make it a valuable intermediate. Understanding these aspects empowers researchers to effectively utilize this compound in their synthetic endeavors. Reliable sourcing from experienced chemical manufacturers ensures the quality and consistency necessary for successful R&D outcomes.