For pharmaceutical and biotech companies, the efficiency and success of their research and development pipelines are heavily reliant on the quality and availability of chemical intermediates. JQ-1 Carboxylic Acid (CAS: 202592-23-2) has become an indispensable compound, particularly in the rapidly expanding field of targeted protein degradation (TPD) through PROTACs. This article provides insights from a manufacturer's perspective on why researchers should buy JQ-1 Carboxylic Acid and what to look for in a supplier.

The Value Proposition of JQ-1 Carboxylic Acid

JQ-1 Carboxylic Acid is a derivative of the highly selective BET (Bromodomain and Extra-Terminal) protein inhibitor, (+)-JQ1. Its primary utility lies in its role as a molecular 'warhead' for PROTAC synthesis. By targeting BET proteins, which are key regulators of gene transcription, JQ-1 Carboxylic Acid enables the development of therapeutic agents that can selectively degrade these proteins. The carboxylic acid functional group is critical, acting as a versatile handle for conjugation, allowing chemists to attach linkers and E3 ligase-binding moieties to create functional PROTACs. Its consistent performance and targeted mechanism make it a sought-after intermediate for advancing research in areas like oncology and epigenetics.

Key Considerations When You Buy JQ-1 Carboxylic Acid

As a manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. understands the critical factors that R&D scientists and procurement specialists consider:

  • Purity Standards: We ensure our JQ-1 Carboxylic Acid meets high purity specifications (e.g., ≥97% by HPLC) to guarantee reliable results in complex synthesis.
  • Chemical Structure: The precisely defined chemical structure (C19H17ClN4O2S) and its CAS number (202592-23-2) are crucial for validation and integration into research protocols.
  • PROTAC Utility: Its inherent ability to bind BET bromodomains and its reactive carboxylic acid group make it a cornerstone for developing BET-targeting PROTACs.
  • Supply Chain Reliability: Partnering with a stable manufacturer ensures consistent availability, preventing delays in critical research timelines.

Sourcing JQ-1 Carboxylic Acid from a reputable manufacturer in China offers advantages in terms of cost-effectiveness and accessibility. We pride ourselves on being a leading supplier, committed to delivering high-quality chemical intermediates that drive innovation in drug discovery. For your PROTAC synthesis needs, we invite you to contact NINGBO INNO PHARMCHEM CO.,LTD. to learn more about our JQ-1 Carboxylic Acid and to request a quote.