In the dynamic field of chemical and pharmaceutical research, the ability to precisely link molecules is paramount. Bioconjugation, the process of covalently attaching one molecule to another, has revolutionized areas from drug development to diagnostics. Central to many advanced bioconjugation strategies is the use of specialized linkers, and among the most versatile is Azido-PEG4-carboxylic acid (CAS: 1257063-35-6). As a leading manufacturer and supplier in China, we are committed to providing researchers with high-quality chemical intermediates like this essential PEG linker.

Understanding Azido-PEG4-carboxylic Acid: The Backbone of Modern Bioconjugation

Azido-PEG4-carboxylic acid is a bifunctional molecule, meaning it possesses two distinct reactive groups: an azide group and a carboxylic acid group. These functionalities are strategically positioned at either end of a flexible, hydrophilic polyethylene glycol (PEG) chain. The PEG spacer itself offers significant advantages, including enhanced water solubility, increased stability, and reduced immunogenicity for the final conjugate. This makes it an indispensable tool for anyone looking to buy advanced chemical reagents for complex biological applications.

The azide group (-N3) is a cornerstone of modern bio-orthogonal chemistry, particularly the 'click chemistry' reaction. Specifically, it readily reacts with alkynes in a [3+2] cycloaddition to form a highly stable triazole ring. This reaction is efficient, highly specific, and can be performed under mild physiological conditions, making it ideal for labeling and conjugating biomolecules such as proteins, peptides, and nucleic acids. Researchers often search for suppliers of azido-PEG4-carboxylic acid in China to ensure a reliable and cost-effective source for their ongoing projects.

The carboxylic acid group (-COOH) on the other end of the molecule offers another avenue for conjugation. It can be activated using standard coupling reagents (like EDC or HATU) and subsequently reacted with primary amines to form a stable amide bond. This dual functionality allows for diverse conjugation strategies, enabling the creation of sophisticated constructs like Antibody-Drug Conjugates (ADCs), targeted drug delivery systems, and functionalized nanoparticles.

Why Choose a Chinese Manufacturer for Your Azido-PEG4-carboxylic Acid Needs?

As a dedicated manufacturer and supplier, we pride ourselves on delivering Azido-PEG4-carboxylic acid with a guaranteed purity of 97% minimum. The demand for high-purity chemical intermediates in pharmaceutical research and development is constant, and sourcing from a reputable Chinese supplier like us ensures not only competitive price but also consistent quality. We understand the critical nature of these materials in producing reliable research outcomes and commercial products. Whether you are looking to purchase small quantities for laboratory research or bulk orders for larger-scale manufacturing, our streamlined production and supply chain management are designed to meet your demands efficiently. We also offer customized synthesis solutions, further solidifying our role as a valuable partner in your scientific endeavors.

Applications Driving Innovation

The applications for Azido-PEG4-carboxylic acid are vast and continuously expanding:

  • Antibody-Drug Conjugates (ADCs): This linker is crucial for attaching cytotoxic drugs to antibodies, enabling targeted cancer therapy. The PEG chain helps improve the pharmacokinetic properties of the ADC.
  • Drug Delivery Systems: Beyond ADCs, it's used to PEGylate small molecule drugs, nanoparticles, and other therapeutic agents to enhance their circulation time and solubility.
  • Surface Modification: The molecule can be used to functionalize surfaces, creating biocompatible or reactive platforms for biosensors or biomaterials.
  • Peptide and Protein Labeling: For imaging or diagnostic purposes, Azido-PEG4-carboxylic acid can be used to attach fluorescent dyes or other labels to peptides and proteins via click chemistry.

Researchers actively seeking to buy Azido-PEG4-carboxylic acid often look for clear specifications, reliable batch-to-batch consistency, and readily available technical support. We provide all of this, along with a commitment to innovation and customer satisfaction. For those exploring CAS 1257063-35-6 chemical intermediate price, reaching out to us directly will provide the most accurate and competitive quotation.

In summary, Azido-PEG4-carboxylic acid is a powerful chemical tool for modern science. As a leading Chinese manufacturer and supplier, we offer this critical intermediate with high purity and reliable service, empowering researchers and pharmaceutical companies worldwide to push the boundaries of innovation. Contact us today to inquire about procurement and explore how our products can support your next breakthrough.