In the complex landscape of chemical synthesis, reliable and high-purity intermediates are the foundation of successful research and product development. Azido-PEG4-carboxylic acid (CAS: 1257063-35-6) is one such intermediate, prized for its bifunctional nature and its utility in a wide array of applications, particularly in bioconjugation and pharmaceutical synthesis. As a prominent chemical manufacturer and supplier originating from China, we are dedicated to providing this critical compound with exceptional quality and consistent availability.

Understanding the Chemical Structure and Functionality

Azido-PEG4-carboxylic acid is characterized by its unique molecular architecture: a flexible, hydrophilic polyethylene glycol (PEG) spacer chain that terminates at one end with an azide group (-N3) and at the other with a carboxylic acid group (-COOH). This specific configuration imbues the molecule with dual reactivity, making it a versatile tool for chemists:

  • Azide Group: This functional group is a key player in 'click chemistry,' most notably the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC). These reactions are highly efficient, specific, and can be performed under mild, bio-orthogonal conditions, making them ideal for labeling and conjugating biomolecules such as proteins, peptides, and nucleic acids. Researchers often seek out suppliers of Azido-PEG4-carboxylic acid for their click chemistry applications.
  • Carboxylic Acid Group: The terminal carboxylic acid provides a reactive site for forming stable amide bonds via activation with coupling reagents (e.g., EDC, HATU) and subsequent reaction with amine-containing molecules. This is a fundamental method for attaching the PEG linker to a variety of substrates.
  • PEG Spacer: The polyethylene glycol chain enhances the water solubility of conjugates, improves their pharmacokinetics, and can shield them from degradation or immune recognition. These properties are highly advantageous in pharmaceutical and biomedical applications.

Why Choose Us as Your Supplier?

As a leading manufacturer based in China, we understand the critical importance of sourcing high-quality chemical intermediates. Our Azido-PEG4-carboxylic acid is produced with a guaranteed minimum purity of 97%, ensuring that your synthesis and conjugation reactions proceed reliably. We prioritize consistency and quality across all our batches. For procurement professionals, investigating the CAS 1257063-35-6 chemical intermediate price through direct inquiry with us will reveal the value of partnering with a dedicated manufacturer.

We are equipped to handle a wide range of order sizes, from small quantities for initial research to bulk orders for large-scale manufacturing. Our efficient supply chain and commitment to customer service ensure that you can confidently purchase this essential reagent and receive it promptly. We aim to be your trusted partner for all your chemical intermediate needs.

Key Applications and Areas of Innovation:

  • Antibody-Drug Conjugates (ADCs): Used to link cytotoxic payloads to monoclonal antibodies for targeted cancer therapies.
  • Drug Delivery Systems: Facilitates PEGylation of small molecules, peptides, and nanoparticles to improve their therapeutic profiles.
  • Biomolecule Labeling: Essential for attaching fluorescent dyes, affinity tags, or other labels to proteins, nucleic acids, and small molecules.
  • Surface Modification: Enables the creation of biocompatible or functionalized surfaces for medical devices and biosensors.
  • PROTAC Synthesis: Serves as a linker component in the design of proteolysis-targeting chimeras.

Azido-PEG4-carboxylic acid is a testament to the power of well-designed chemical intermediates in advancing scientific frontiers. We invite you to experience the quality and reliability of our products. Contact us today to discuss your requirements and learn how our high-purity Azido-PEG4-carboxylic acid can support your synthesis projects and innovations.