Precision is paramount in chemical synthesis and bioconjugation, especially in the pharmaceutical and biotechnology sectors. The ability to precisely attach molecules to each other under controlled conditions is fundamental to developing novel therapeutics, diagnostics, and functional materials. Azido-PEG4-carboxylic acid (CAS: 1257063-35-6) is a highly valued intermediate that enables such precision, offering a unique combination of functionalities. As a leading chemical manufacturer and supplier in China, we are committed to providing researchers and industries with this essential building block.

The Dual Functionality of Azido-PEG4-carboxylic Acid

Azido-PEG4-carboxylic acid is a bifunctional linker, meaning it possesses two distinct reactive groups: an azide (-N3) and a carboxylic acid (-COOH). These groups are separated by a flexible, hydrophilic polyethylene glycol (PEG) chain of four ethylene oxide units. This structure provides several key advantages:

  • Click Chemistry Compatibility: The azide group is a cornerstone of 'click chemistry,' a set of highly efficient and specific reactions. It readily participates in cycloaddition reactions with alkynes, forming a stable triazole ring. This bio-orthogonal reaction is critical for conjugating sensitive biomolecules without disruption.
  • Amide Bond Formation: The carboxylic acid group can be activated for coupling with amine-containing molecules, forming stable amide bonds. This is a well-established method for linking peptides, proteins, and other amine-bearing structures.
  • PEG Spacer Benefits: The PEG chain enhances the water solubility of conjugates, improves their pharmacokinetic profiles, and can reduce immunogenicity – all highly desirable attributes in pharmaceutical applications.

This versatile combination of features makes Azido-PEG4-carboxylic acid an indispensable tool for researchers aiming to create complex and highly functional molecules. When looking to buy such specialized reagents, identifying a reliable supplier in China is key to ensuring quality and value.

Applications Driving Scientific Advancements

The applications of Azido-PEG4-carboxylic acid span across multiple disciplines:

  • Antibody-Drug Conjugates (ADCs): This linker is extensively used to attach potent cytotoxic drugs to antibodies, enabling targeted cancer therapy. The PEG spacer helps maintain antibody stability and drug solubility.
  • Drug Delivery Systems: It can be used to PEGylate small molecules or nanoparticles, improving their delivery efficiency and therapeutic index.
  • Biomolecule Labeling: Researchers use it to attach fluorescent dyes, biotin, or other probes to proteins, peptides, and oligonucleotides for imaging, detection, or purification.
  • Surface Modification: The compound can be employed to functionalize surfaces of medical devices, biosensors, or materials, imparting specific biocompatibility or reactivity.

Why Choose Our Products?

As a leading manufacturer in China, we offer Azido-PEG4-carboxylic acid with a guaranteed purity of 97% minimum, ensuring exceptional performance in your sensitive applications. We understand the critical need for consistent quality and reliable supply in pharmaceutical R&D and manufacturing. When you inquire about the CAS 1257063-35-6 chemical intermediate price, you will find our direct manufacturing offers competitive terms. We are dedicated to supporting your research and development endeavors by providing high-quality chemical intermediates and robust logistical support. Companies seeking to purchase this vital reagent can trust our expertise and commitment to excellence.

In conclusion, Azido-PEG4-carboxylic acid is a cornerstone intermediate for precise chemical conjugation. Its unique bifunctionality, combined with the benefits of a PEG spacer, makes it invaluable for a wide range of advanced applications. We invite you to partner with us for your supply needs and leverage our high-quality intermediates to drive your innovation forward.