For researchers and chemists engaged in the intricate field of peptide synthesis, selecting the right building blocks is paramount. Among these crucial components, Fmoc-Lys(Boc)-OH stands out as a widely utilized and highly effective derivative. This article delves into its significance, offering insights for procurement managers and research scientists seeking to optimize their peptide synthesis workflows. As a leading manufacturer and supplier in China, we aim to provide clarity on why this particular amino acid derivative is a go-to choice.

Fmoc-Lys(Boc)-OH, chemically known as N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-t-butyloxycarbonyl-L-lysine, is characterized by two key protective groups: the Fmoc group on the alpha-amino nitrogen and the Boc group on the side-chain epsilon-amino nitrogen. This dual protection strategy is central to its utility in Solid-Phase Peptide Synthesis (SPPS). The Fmoc group is base-labile, allowing for its facile removal under mild basic conditions (e.g., piperidine treatment) to reveal the alpha-amino group for subsequent coupling. Crucially, the Boc group on the lysine side chain is acid-labile, providing orthogonal protection. This means it remains intact during the Fmoc deprotection steps but can be selectively removed during the final cleavage of the synthesized peptide from the resin using reagents like trifluoroacetic acid (TFA).

The stability of the Boc group under standard Fmoc deprotection conditions is a significant advantage for anyone looking to buy Fmoc-Lys(Boc)-OH. It prevents unwanted side reactions on the lysine side chain, ensuring the integrity of the peptide sequence being built. This reliability translates into higher yields and purer final products, which are critical factors for researchers in drug development and biochemical studies. When considering the price of this material, it's important to weigh it against the enhanced efficiency and reduced purification efforts it facilitates.

Sourcing high-quality Fmoc-Lys(Boc)-OH is key to successful peptide synthesis. As a reputable supplier, we ensure that our product meets high purity standards, often exceeding 99%. This level of purity is essential for minimizing the formation of deletion or truncated sequences, common challenges in SPPS. Procurement managers should look for suppliers who provide comprehensive Certificates of Analysis (CoA) detailing purity via HPLC and other relevant analytical methods. The CAS number, 71989-26-9, is a critical identifier when searching for this specific chemical compound.

For those interested in large-scale projects or requiring a consistent supply, bulk orders and custom quotes are readily available. Partnering with a reliable manufacturer in China like us offers the advantage of competitive pricing and dependable logistics. Whether you are synthesizing therapeutic peptides, diagnostic tools, or conducting fundamental research, ensuring a stable supply of Fmoc-Lys(Boc)-OH is a strategic step towards achieving your project goals. We encourage research labs and pharmaceutical companies to reach out for a quote or to discuss their specific needs for this vital peptide synthesis reagent.