The Suzuki-Miyaura cross-coupling reaction, a Nobel Prize-winning methodology, has revolutionized organic synthesis. At its heart are organoboron compounds, with boronic acids being particularly popular due to their stability and low toxicity. Among these, 3,4,5-Trifluorophenylboronic acid stands out as a versatile and valuable building block. If you are looking to buy this essential reagent, understanding its role is key.

What is 3,4,5-Trifluorophenylboronic Acid?
3,4,5-Trifluorophenylboronic acid (CAS No: 143418-49-9) is an organoboron compound featuring a phenyl ring substituted with three fluorine atoms at the 3, 4, and 5 positions, and a boronic acid functional group (-B(OH)2). Its molecular formula is C6H4BF3O2, with a molecular weight of approximately 175.90 g/mol. Typically supplied as a white to off-white crystalline solid, it demonstrates good stability, a critical factor for laboratory and industrial use.

The Power of Fluorine in Synthesis
The presence of fluorine atoms significantly influences the electronic properties of the phenyl ring. Fluorine is highly electronegative, leading to electron-withdrawing effects. This can impact the reactivity of the boronic acid in cross-coupling reactions and the properties of the final synthesized molecule. For instance, fluorinated aromatic compounds often exhibit enhanced lipophilicity, metabolic stability, and unique electronic characteristics, making them highly sought after in the pharmaceutical and materials science sectors.

Key Applications in Organic Synthesis
1. Suzuki Coupling Reactions: This is perhaps the most prominent application. 3,4,5-Trifluorophenylboronic acid readily participates in palladium-catalyzed Suzuki coupling reactions with aryl, vinyl, or alkyl halides/triflates. This allows for the efficient formation of C-C bonds, creating complex fluorinated biaryl systems or other substituted aromatic compounds. Researchers often seek this specific boronic acid to introduce a trifluorophenyl moiety into their target molecules. If you need to buy this for your Suzuki reactions, ensure you source from a reputable manufacturer.

2. Pharmaceutical Intermediates: The unique properties imparted by the trifluorophenyl group make it a valuable building block in drug discovery and development. It can be incorporated into drug candidates to modulate their pharmacokinetic and pharmacodynamic profiles. As a supplier of pharmaceutical intermediates, we understand the stringent purity requirements for such applications.

3. Materials Science: In materials science, fluorinated aromatic compounds are used in the development of advanced polymers, liquid crystals, and organic electronic materials. The trifluorophenyl group can influence thermal stability, dielectric properties, and intermolecular interactions. We provide this chemical building block to researchers and manufacturers working on next-generation materials.

Sourcing High-Purity 3,4,5-Trifluorophenylboronic Acid
When selecting a supplier for 3,4,5-Trifluorophenylboronic acid, purity is paramount. We offer this compound with an assay of ≥98.0%, ensuring that your synthetic processes proceed smoothly and yield high-quality products. As a manufacturer and supplier based in China, we are committed to providing competitive pricing and reliable supply chains. Whether you are a research scientist needing small quantities for experimentation or a production manager requiring bulk orders, we can meet your needs. To inquire about the price or to place a purchase order, contact our sales team. We are dedicated to being your trusted partner for specialty chemicals and organic synthesis reagents.