The precise manipulation of ion channel activity is a cornerstone of modern pharmaceutical research, enabling the development of targeted therapies for a multitude of diseases. Within the vast landscape of ion channels, the KCNK3, also known as TASK-1, a member of the two-pore domain potassium channel family, has garnered significant attention. Its role in neuronal excitability, pain sensation, and even cardiac function makes it a compelling target for therapeutic intervention. ML365 has emerged as a key pharmacological tool for dissecting these functions.

ML365, identified by CAS number 947914-18-3, is a small molecule inhibitor celebrated for its potent and exceptionally selective action against the KCNK3/TASK1 channel. Studies have consistently reported a low IC50 value (around 4 nM) for TASK-1 inhibition, accompanied by a high degree of selectivity over related channels like TASK-3 and other common potassium channel subtypes. This specificity is invaluable in pharmaceutical research, allowing scientists to isolate the effects of TASK-1 modulation without significant confounding from off-target interactions.

For researchers and procurement managers in the pharmaceutical sector, sourcing high-quality, reliably characterized compounds is paramount. We understand this need and proudly offer ML365 as a top-tier pharmaceutical intermediate. Our commitment as a manufacturer ensures that the ML365 we supply meets stringent purity specifications (≥98% by HPLC), guaranteeing consistent performance in your critical assays and research projects. When you choose to buy ML365 from us, you are securing a quality reagent from a trusted global supplier.

The utility of ML365 extends across various research applications within the pharmaceutical industry. It serves as an excellent pharmacological probe for in vitro studies, helping to characterize the physiological and pathological roles of TASK-1. Furthermore, its properties make it a valuable lead compound for further optimization in the discovery of novel therapeutics targeting conditions where TASK-1 activity is dysregulated. If you are seeking to purchase ML365 for your next research endeavor, our efficient supply chain ensures timely delivery.

We aim to be your preferred partner for essential research chemicals. We offer competitive pricing for ML365, whether you require small research quantities or bulk orders for larger projects. As a dedicated manufacturer, we also have the capability for custom synthesis. Please contact us to request a quote, obtain a sample, or discuss your specific requirements for sourcing ML365 or other specialized pharmaceutical intermediates.

Invest in the precision and reliability that your pharmaceutical research demands. Partner with us to access high-quality ML365 and contribute to the development of next-generation therapeutics targeting potassium channel function.