In the intricate world of organic synthesis and pharmaceutical development, specific chemical building blocks play an indispensable role in creating novel therapeutic agents. N-Boc-piperidine-3-methanol, identified by its CAS number 116574-71-1, stands out as a significant heterocyclic intermediate. Its unique structural features and chemical reactivity make it a sought-after compound for researchers aiming to develop new drugs and advanced materials. This article delves into the properties, synthesis, and applications that make N-Boc-piperidine-3-methanol a cornerstone in modern chemical innovation.

Chemically, N-Boc-piperidine-3-methanol features a six-membered piperidine ring, which is a saturated heterocyclic amine. The 'N-Boc' designation refers to the tert-butoxycarbonyl group attached to the nitrogen atom of the piperidine ring. This protecting group is crucial as it modulates the reactivity of the nitrogen, making it less nucleophilic and more stable under various reaction conditions, while also being readily removable when desired. The presence of a hydroxymethyl (-CH2OH) group at the 3-position of the piperidine ring provides a reactive site for further functionalization, such as esterification, etherification, or oxidation.

The synthesis of N-Boc-piperidine-3-methanol typically involves the protection of the nitrogen atom of 3-piperidinemethanol with di-tert-butyl dicarbonate. This reaction, often carried out in solvents like tetrahydrofuran in the presence of a base such as triethylamine, yields the protected intermediate with high efficiency. The resulting product is commonly obtained as a white to off-white crystalline powder, with a melting point typically in the range of 77-81 °C. Its solubility in polar organic solvents like methanol and DMF facilitates its use in various synthetic procedures.

The significance of N-Boc-piperidine-3-methanol in pharmaceutical research stems from its role as a versatile intermediate. It is employed in the synthesis of a wide array of biologically active compounds, including those investigated for their potential as kinase inhibitors, receptor antagonists, and modulators of various biological pathways. For example, it has been used in the synthesis of compounds that inhibit Pim-1 kinase, target vasopressin receptors, or act as CXCR4 antagonists, showing promise in areas like oncology and virology. The ability to buy this intermediate from reliable manufacturers allows researchers to accelerate their drug discovery efforts.

For companies and research institutions that require N-Boc-piperidine-3-methanol, sourcing it from reputable manufacturers and suppliers is essential. As a global supplier of fine chemicals, we offer this critical intermediate, emphasizing purity and consistent quality. Understanding the needs of the R&D sector, we ensure that our product specifications meet industry standards, making it suitable for complex synthetic routes. We provide detailed technical data and support to help our clients make informed purchasing decisions.

The availability of N-Boc-piperidine-3-methanol from trusted sources, such as NINGBO INNO PHARMCHEM CO.,LTD., simplifies the procurement process for researchers worldwide. By offering competitive pricing and ensuring product availability, we aim to be a preferred partner for pharmaceutical companies and research institutions. Whether you are initiating a new drug discovery project or scaling up existing synthesis, our commitment to quality and service makes us an ideal choice for sourcing this vital heterocyclic building block.