In the dynamic field of cancer research, access to highly specific and potent molecular tools is crucial for unraveling complex disease mechanisms and developing novel therapeutic strategies. NSC-87877, a powerful inhibitor of protein tyrosine phosphatases (PTPs) SHP2 and SHP1, stands out as a valuable asset for laboratories investigating cancer biology. This article delves into the importance of NSC-87877, its specific applications, and how researchers can reliably purchase this compound.

The Role of PTPs in Cancer: A Brief Overview

Protein tyrosine phosphatases are enzymes that play a critical role in cellular signaling by removing phosphate groups from tyrosine residues of proteins. This dephosphorylation process is vital for regulating numerous cellular functions, including cell proliferation, survival, and migration. Aberrant PTP activity, particularly of SHP2 and SHP1, has been increasingly linked to the development and progression of various cancers, including neuroblastoma, making them attractive targets for therapeutic intervention.

NSC-87877: Mechanism and Applications in Research

NSC-87877 (CAS 56990-57-9) is recognized for its potent inhibitory effects on SHP2 and SHP1. Its efficacy is demonstrated by its low IC50 values against these targets, as well as its demonstrated ability to inhibit EGF-induced Erk1/2 activation and affect cell viability in specific cancer cell lines. Specifically, research has highlighted NSC-87877's potential in investigating neuroblastoma, where it has shown to inhibit tumor growth and induce apoptosis. For research labs focusing on:

  • Neuroblastoma Therapeutics: Studying the effects of NSC-87877 provides insights into novel treatment avenues for neuroblastoma. Researchers can buy this compound to conduct in vitro and in vivo experiments exploring its anti-cancer mechanisms.
  • Signal Transduction Pathway Analysis: Understanding the downstream effects of PTP inhibition is vital. NSC-87877 enables detailed investigations into how modulating SHP2 and SHP1 activity impacts cellular signaling pathways relevant to cancer progression.
  • Drug Screening and Development: As a well-defined chemical tool, NSC-87877 can be used in screening assays to identify synergistic drug combinations or to study resistance mechanisms.

Sourcing NSC-87877: Quality and Value from China

For research institutions and pharmaceutical companies, securing a consistent supply of high-quality NSC-87877 is essential. As a direct manufacturer and supplier from China, we offer significant advantages:

  • High Purity: Our NSC-87877 is supplied with a purity of ≥98% (HPLC), ensuring reliable and reproducible experimental outcomes.
  • Competitive Pricing: Direct sourcing eliminates intermediary costs, allowing you to purchase this critical research chemical at a more accessible price point.
  • Availability: We maintain a stable supply, ensuring that research projects are not hampered by stockouts.

Purchasing for Your Lab

We are committed to supporting the scientific community by providing access to essential research chemicals. If your research involves SHP2/SHP1 inhibition, cancer pathways, or neuroblastoma studies, we encourage you to consider NSC-87877. Contact us to discuss your requirements, request a quotation, or inquire about bulk purchase options. We are your trusted partner for high-quality research chemicals, facilitating your groundbreaking discoveries.