Neuroblastoma remains a significant challenge in pediatric oncology, prompting ongoing research into novel therapeutic targets and treatment strategies. Within this critical research area, compounds like NSC-87877 play a pivotal role. As a potent inhibitor of protein tyrosine phosphatases (PTPs), specifically SHP2 and SHP1, NSC-87877 offers researchers a powerful tool to investigate the complex signaling pathways that drive neuroblastoma growth and survival. This article provides an overview of NSC-87877's significance and guides researchers on how to acquire it for their studies.

The Significance of PTP Inhibition in Neuroblastoma Research

Protein tyrosine phosphatases are crucial regulators of cellular processes, and their dysregulation is often implicated in cancer. SHP2 and SHP1, the primary targets of NSC-87877, are involved in a wide array of signaling pathways that control cell proliferation, differentiation, and apoptosis. Research has indicated that the activity of these phosphatases is altered in neuroblastoma, making them promising targets for therapeutic intervention. NSC-87877, with its high specificity and potency against these targets, allows researchers to probe these pathways effectively.

NSC-87877: Applications and Research Value

NSC-87877 (CAS 56990-57-9) is scientifically valued for its ability to inhibit SHP2 and SHP1, with demonstrated low IC50 values. Its utility extends to various research applications:

  • Targeted Cancer Therapy Studies: Pre-clinical research has shown that NSC-87877 can inhibit neuroblastoma cell proliferation and induce apoptosis, suggesting its potential as a therapeutic agent or as a compound to study in combination therapies. Researchers can purchase this chemical to conduct these vital investigations.
  • Pathway Elucidation: By inhibiting SHP2 and SHP1, researchers can unravel the intricate signaling cascades that contribute to neuroblastoma development, providing critical insights for future treatment strategies.
  • Biochemical and Pharmacological Studies: The high purity (≥98% by HPLC) of NSC-87877 ensures reliable data in enzyme assays and pharmacological profiling, crucial for drug discovery pipelines.

Procuring High-Quality NSC-87877 from China

For research institutions and pharmaceutical companies, ensuring a consistent supply of high-quality NSC-87877 is paramount. As a dedicated manufacturer and supplier from China, we offer several advantages:

  • Quality Assurance: We guarantee the purity and potency of our NSC-87877, critical for the integrity of research findings.
  • Competitive Pricing: Direct sourcing from our manufacturing facilities provides cost-effective procurement solutions.
  • Reliable Supply Chain: Our established production capabilities ensure a steady availability of this important research chemical.

How to Purchase for Your Research Needs

We are committed to supporting advancements in neuroblastoma research and other fields by providing researchers with access to high-quality chemical tools. If your work requires potent PTP inhibitors like NSC-87877, we encourage you to reach out to us. Request a quotation, inquire about bulk purchasing options, and discover the benefits of partnering with a reliable supplier. We aim to be your go-to source for essential research chemicals, facilitating your groundbreaking scientific endeavors.