In the realm of scientific research, the quality and reliability of chemical reagents are paramount to achieving accurate and reproducible results. For researchers investigating cellular signaling pathways, particularly those involving protein tyrosine phosphatases (PTPs) like SHP2 and SHP1, NSC-87877 stands out as a crucial tool. This article highlights the importance of NSC-87877, its key applications, and the strategic advantages of procuring this high-purity research chemical from reliable suppliers, especially those based in China.

The Critical Role of NSC-87877 in PTP Research

NSC-87877, identified by CAS number 56990-57-9, is a potent inhibitor of SHP2 and SHP1 protein tyrosine phosphatases. These enzymes are integral to a multitude of cellular processes, and their aberrant activity is a hallmark of many diseases, including various forms of cancer. The compound's well-documented biological activity, including its potent inhibitory effects (low IC50 values) and its influence on cell signaling pathways and cancer cell viability, makes it an indispensable reagent for a wide array of research applications. Its use in studies related to neuroblastoma further underscores its relevance in understanding disease pathogenesis and developing targeted therapies.

Key Research Applications:

  • Target Validation: Researchers use NSC-87877 to validate SHP2 and SHP1 as therapeutic targets in cancer and other diseases.
  • Mechanism of Action Studies: Its specific inhibitory action allows for detailed investigation into the downstream effects of PTP modulation on cellular pathways.
  • Pre-clinical Drug Discovery: The compound serves as a valuable tool in screening for novel therapeutic agents or combinations that target PTPs.

Strategic Sourcing: Benefits of Chinese Manufacturers

For laboratories requiring consistent access to high-quality research chemicals, sourcing directly from established manufacturers offers distinct advantages. When looking to purchase NSC-87877, partnering with a reputable Chinese supplier provides:

  • High Purity Guarantee: Reputable suppliers ensure that NSC-87877 meets stringent purity standards, often ≥98% (HPLC), which is critical for experimental accuracy.
  • Competitive Pricing: Direct sourcing from manufacturers can significantly reduce costs, making essential research reagents more accessible.
  • Reliable Supply: A stable manufacturing base ensures consistent availability, preventing research disruptions due to supply chain issues.

Your Trusted Partner for Research Chemicals

We are committed to supporting the scientific community by providing researchers with premium-grade chemicals like NSC-87877. If your work involves the study of protein tyrosine phosphatases, cancer signaling pathways, or neuroblastoma research, we encourage you to explore our offerings. Contact us to request a quotation, inquire about bulk purchase discounts, and secure a reliable supply of this vital research compound. By partnering with us, you gain access to quality, value, and a dependable supply chain.