In the competitive landscape of pharmaceutical manufacturing, optimizing the production of critical drugs like Nevirapine is a continuous effort. Central to this process is the reliable procurement of high-quality intermediates. Among these, 3-Amino-2-chloro-4-picoline (also known as 2-Chloro-3-amino-4-methylpyridine, CAS: 133627-45-9) plays a pivotal role as a key building block for Nevirapine, an important antiretroviral medication used in HIV/AIDS treatment. For procurement managers and R&D scientists, understanding the specifications and sourcing strategies for this compound is essential.

Understanding 3-Amino-2-chloro-4-picoline Specifications

This chemical intermediate is typically supplied as an off-white to yellowish powder. Key specifications that buyers should focus on include:

  • Purity: A minimum purity of 99.0% is often required for pharmaceutical applications to ensure the efficacy and safety of the final drug product. Reputable manufacturers provide Certificates of Analysis (CoA) detailing purity levels determined by methods like HPLC.
  • Moisture Content: Low moisture content (e.g., <0.04%) is desirable as it contributes to product stability and handling ease.
  • Heavy Metals: Limits on heavy metals (e.g., <0.002%) are crucial for pharmaceutical intermediates to prevent contamination of the final API.
  • CAS Number: 133627-45-9 is the definitive identifier for this compound.

The Nevirapine Connection

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that has been a cornerstone in HIV/AIDS therapy for decades. The synthesis of Nevirapine involves a multi-step process, and 3-Amino-2-chloro-4-picoline serves as a fundamental structural component that is modified and incorporated into the final drug molecule. The efficiency of the Nevirapine manufacturing process is directly linked to the consistent quality and availability of this precursor.

Sourcing Strategies for Procurement Managers

When looking to buy 3-Amino-2-chloro-4-picoline, procurement professionals should adopt a strategic approach:

  • Identify Reliable Manufacturers: Focus on suppliers with proven track records in producing pharmaceutical intermediates. Manufacturers in China are often highly competitive in terms of both quality and price.
  • Request Comprehensive Quotes: Obtain detailed pricing information based on your required quantities. Factor in lead times, packaging options (e.g., 25kg cardboard drums), and shipping arrangements.
  • Verify Quality Control: Ensure that suppliers adhere to stringent quality management systems. Companies like NINGBO INNO PHARMCHEM CO., LTD. are known for their commitment to quality in supplying chemical intermediates.
  • Build Strong Supplier Relationships: Establishing long-term partnerships with trusted suppliers can lead to better pricing, prioritized supply, and collaborative problem-solving.

By diligently evaluating suppliers and understanding the critical specifications, procurement teams can secure a stable and high-quality supply of 3-Amino-2-chloro-4-picoline, thereby ensuring uninterrupted production of essential antiretroviral drugs like Nevirapine.