The efficiency and success of any organic synthesis project hinge on the quality and reactivity of the starting materials and intermediates used. For chemists engaged in developing new compounds or optimizing existing synthetic pathways, understanding the utility of versatile building blocks is paramount. 1-Chloro-2-iodobenzene (CAS 615-41-8) is one such compound that offers significant advantages due to its unique chemical structure and reactivity. As a dedicated manufacturer of organic synthesis intermediates, we aim to provide insights into how this chemical can elevate your research and production processes.

Understanding the Chemistry of 1-Chloro-2-iodobenzene

1-Chloro-2-iodobenzene, often identified by its CAS number 615-41-8, is a disubstituted benzene derivative featuring a chlorine atom and an iodine atom at ortho positions. This arrangement is crucial. Iodine atoms are known for their excellent leaving group ability and participation in metal-catalyzed cross-coupling reactions. Chlorine, while less reactive in such couplings, offers another site for potential functionalization or can influence the electronic properties of the molecule. The compound typically presents as a light yellow liquid, with a high boiling point of 234-235°C, making it manageable for most laboratory and industrial synthesis operations. For those looking to buy 1-chloro-2-iodobenzene, its purity, often specified at ≥99%, is a critical factor for predictable reaction outcomes.

Key Advantages in Organic Synthesis

The primary advantage of using 1-Chloro-2-iodobenzene lies in its bifunctional nature and the differential reactivity of its halogen substituents. This allows chemists to perform sequential or selective reactions, a cornerstone of complex molecule synthesis. For instance:

  • Palladium-Catalyzed Cross-Coupling Reactions: The iodine atom readily undergoes oxidative addition with palladium catalysts, initiating crucial C-C bond forming reactions like Suzuki-Miyaura coupling (with boronic acids), Sonogashira coupling (with terminal alkynes), and Heck reactions (with alkenes). This capability is fundamental in building intricate carbon frameworks common in pharmaceuticals, agrochemicals, and advanced materials.
  • Directed Ortho Metalation (DoM): The chlorine substituent can sometimes act as a directing group in lithiation reactions, allowing for regioselective functionalization of the aromatic ring, further expanding the synthetic utility.
  • Building Block for Heterocycles: It can serve as a precursor for synthesizing various heterocyclic compounds, which are prevalent in many biologically active molecules and functional materials.

When researchers purchase 1-chloro-2-iodobenzene, they gain access to a versatile tool that can streamline synthetic routes, potentially reducing the number of steps and improving overall yields. This translates to significant time and cost savings in research and development.

Why Choose Us as Your Supplier?

As a leading 1-chloro-2-iodobenzene supplier and manufacturer based in China, we pride ourselves on delivering exceptional quality and value. Our commitment to stringent quality control ensures that the ≥99% purity of our product is consistently maintained, minimizing impurities that could interfere with sensitive synthetic processes. We understand the importance of reliable supply chains, and our efficient production and logistics ensure that your orders are processed and delivered promptly.

For businesses looking for competitive 1-chloro-2-iodobenzene price, direct sourcing from us eliminates intermediaries, offering cost advantages without compromising on quality. We cater to both small-scale research needs and large-scale industrial requirements, providing flexible packaging and shipping options to meet your specific demands. Exploring options to buy 1-chloro-2-iodobenzene from a trusted manufacturer like us is a strategic move towards securing your project's success.

In conclusion, 1-Chloro-2-iodobenzene is a powerful intermediate that offers synthetic chemists remarkable flexibility and control. By partnering with a reputable manufacturer and supplier, you ensure access to this essential chemical with the quality and reliability your projects demand. We encourage you to reach out for a quote and sample to experience the benefits firsthand.