The continuous evolution of scientific research demands specialized tools that enable deeper exploration of biological mechanisms. In the realm of neuroscience, understanding the intricate workings of ion channels and their impact on conditions like depression is a key focus. PE 22-28, a potent peptide inhibitor, has emerged as a vital compound for researchers in this field, offering precise modulation of TREK-1 channels. This article aims to elucidate the mechanism of action, explore its diverse applications, and provide crucial information for purchasing PE 22-28 from a reliable manufacturer.

PE 22-28, identified by its CAS number 1801959-12-5, functions as a highly selective inhibitor of TREK-1 (TWIK-related acid-soluble domain-containing potassium channel 1). These channels play a significant role in neuronal excitability and are increasingly recognized for their involvement in mood regulation and pain perception. With a remarkably low IC50 value of 0.12 nM, PE 22-28 offers a high degree of potency and specificity, allowing researchers to precisely target TREK-1 activity in their experimental models. This targeted approach is essential for dissecting complex biological pathways.

The research applications of PE 22-28 are multifaceted, extending across several critical areas of neuroscience. Its demonstrated antidepressant properties, observed in preclinical studies, make it an invaluable reagent for researchers investigating the neurobiological underpinnings of depression. By inhibiting TREK-1, scientists can explore novel therapeutic avenues for mood disorders. Furthermore, PE 22-28 has shown promising neuroprotective effects. Studies have indicated its ability to reduce apoptotic cell death, particularly in beta cells, and enhance hippocampal neurogenesis. These findings suggest potential applications in understanding and treating conditions related to ischemia and stroke, where neuronal survival and regeneration are critical.

For scientists requiring PE 22-28 for their research, securing a reliable source is paramount. As a dedicated manufacturer and supplier of high-purity research chemicals, we offer PE 22-28 with a guaranteed purity of over 99%. Our commitment extends to providing comprehensive technical data, including Certificates of Analysis (CoA) and Safety Data Sheets (SDS), ensuring that our clients have all the necessary information for successful experimental integration. When considering where to buy this peptide, opting for a manufacturer that specializes in peptide synthesis and quality assurance provides the greatest confidence.

The availability of PE 22-28 as a scientific reagent facilitates critical research in areas such as mood disorders, neuroinflammation, and recovery from neurological injury. Our competitive pricing and robust supply chain ensure that researchers can obtain this essential compound efficiently. We understand the importance of accessibility in scientific discovery and strive to make PE 22-28 readily available to the global research community. Inquiries about bulk orders and specific product requirements are always welcome.

In summary, PE 22-28 is a powerful peptide inhibitor with significant implications for advancing our understanding of neurological health and disease. Its precise mechanism of TREK-1 inhibition, coupled with its observed antidepressant and neuroprotective effects, makes it a cornerstone for many research projects. We encourage all researchers to consider us as their trusted supplier for high-quality PE 22-28, and to contact us for purchase inquiries to facilitate their groundbreaking studies.