Polyethylene glycol (PEG) linkers are foundational components in many cutting-edge applications across biotechnology, pharmaceuticals, and materials science. Their inherent hydrophilicity, biocompatibility, and tunable chain length make them ideal for modifying biomolecules and surfaces. Among the most versatile of these linkers is Azido-PEG4-carboxylic acid (CAS: 1257063-35-6), a bifunctional reagent that offers unique advantages for conjugation and drug delivery. As a leading chemical manufacturer and supplier based in China, we are proud to offer this critical intermediate to the global research community.

Understanding the Advantages of PEG Linkers

The PEG chain in Azido-PEG4-carboxylic acid provides a flexible spacer that can significantly impact the properties of conjugated molecules. Key benefits include:

  • Enhanced Solubility: The hydrophilic nature of PEG greatly improves the aqueous solubility of otherwise insoluble compounds, crucial for in vivo applications and formulation.
  • Increased Stability: PEGylation can protect biomolecules from enzymatic degradation, extending their circulation half-life and improving their stability.
  • Reduced Immunogenicity: The bulky PEG chains can shield epitopes on proteins or other molecules, minimizing unwanted immune responses.
  • Controlled Spacing: PEG linkers provide a defined distance between conjugated entities, which can be critical for optimal interaction or functionality.

Azido-PEG4-carboxylic Acid: A Gateway to Advanced Conjugation

Azido-PEG4-carboxylic acid combines the benefits of a PEG linker with two highly useful functional groups: a terminal azide and a terminal carboxylic acid. This bifunctionality opens up numerous synthetic pathways:

  • Click Chemistry: The azide group is perfectly suited for 'click chemistry' reactions, especially with alkyne-functionalized molecules. This highly efficient and specific reaction forms a stable triazole linkage, making it a preferred method for creating bioconjugates. Researchers frequently search for suppliers of Azido-PEG4-carboxylic acid to access this powerful conjugation tool.
  • Amide Bond Formation: The carboxylic acid group can be activated and reacted with primary amines, forming stable amide bonds. This is a classical and robust method for conjugating molecules, particularly proteins and peptides with accessible amine residues.

These dual reactive capabilities make Azido-PEG4-carboxylic acid an ideal component for developing Antibody-Drug Conjugates (ADCs), PEGylated therapeutics, and functionalized nanoparticles. Its versatility allows researchers to tailor conjugates precisely for their intended applications.

Why Source from a Chinese Manufacturer?

As a premier chemical supplier and manufacturer in China, we are dedicated to providing high-purity reagents like Azido-PEG4-carboxylic acid, with a guaranteed minimum purity of 97%. We understand the importance of reliable sourcing for critical R&D projects and manufacturing. By choosing us, you gain access to competitive pricing for this essential PEG linker, backed by stringent quality control and efficient logistics. For those looking to buy this compound, our direct manufacturing capability ensures consistency and availability.

When researching the CAS 1257063-35-6 chemical intermediate price, engaging with us provides direct access to manufacturer-level pricing and technical expertise. We are equipped to handle orders ranging from small laboratory quantities to bulk industrial requirements, supporting your project at every stage.

Key Applications Driving Innovation:

  • Targeted Drug Delivery: Essential for constructing ADCs and other targeted therapeutic delivery systems.
  • Biomolecule Labeling: Attaching fluorophores, biotin, or other tags to proteins and peptides.
  • Surface Functionalization: Creating biocompatible or reactive surfaces for biosensors and medical devices.
  • PROTAC and Molecular Glue Synthesis: Incorporating into complex linker designs for targeted protein degradation.

Azido-PEG4-carboxylic acid is a powerful tool that embodies the advancements in PEG linker technology. We invite you to explore how our high-quality intermediates and reliable supply chain can support your innovative research and development efforts. Contact us to learn more and secure your supply of this critical reagent.