For procurement managers and R&D scientists in the pharmaceutical sector, sourcing critical intermediates like (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine (CAS: 196597-81-6) is a paramount task. This compound plays a vital role as a key building block in the synthesis of Ramelteon, a widely recognized medication for insomnia. Understanding the nuances of procuring this high-value chemical can significantly impact project timelines and budget efficiency. This guide aims to provide essential insights for buyers looking to purchase this intermediate, focusing on quality, reliability, and cost-effectiveness, particularly when sourcing from China.

Understanding the Product: Key Specifications and Applications

The primary application of (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine lies in its role as a pharmaceutical intermediate. Its precise molecular structure, C13H17NO, with a molecular weight of 203.280, and a CAS number of 196597-81-6, defines its identity. The physical appearance is typically a colorless liquid, with a purity assay of ≥98.0%. This high purity is non-negotiable for pharmaceutical applications, where even trace impurities can affect the efficacy and safety of the final Active Pharmaceutical Ingredient (API). Its specific stereochemistry, denoted by the (S) designation, is crucial for its intended biological activity within the synthesis pathway of Ramelteon.

When you need to buy this intermediate, looking for suppliers who guarantee these specifications is the first step. R&D scientists often search for terms like 'buy (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine' or 'CAS 196597-81-6 price' to identify potential partners.

Sourcing Strategies for Pharmaceutical Intermediates

As a leading manufacturer and supplier in China, we understand the global demand for high-quality pharmaceutical intermediates. When procuring (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine, consider the following:

  • Supplier Verification: Look for manufacturers with a proven track record and robust quality control systems. Online searches for '(S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine supplier China' can help you identify reputable companies.
  • Purity and Assay: Always confirm the product's purity (≥98.0%) and assay. For API synthesis, this is critical for downstream processing and regulatory compliance.
  • Packaging and Storage: Typically supplied in 200 kg drums, proper storage conditions (cool, ventilated place) are vital to maintain its quality.
  • Regulatory Compliance: Ensure the supplier can provide necessary documentation, such as Certificates of Analysis (CoA), and potentially support with DMF filings if required for your final API.
  • Bulk Pricing and Quotations: For substantial R&D projects or commercial manufacturing, requesting quotes for bulk quantities is essential. Companies actively seeking to purchase will often look for 'price of (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine' to compare offers.

The Role of (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine in Ramelteon Synthesis

Ramelteon is a selective agonist of the melatonin receptor types MT1 and MT2, and its synthesis relies heavily on precise chemical precursors. (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine serves as a foundational chiral amine in constructing the final Ramelteon molecule. The stereospecificity of this intermediate ensures that the synthesized API possesses the correct three-dimensional structure, which is vital for effective binding to its intended biological targets. Manufacturers like ourselves are dedicated to producing this intermediate with the enantiomeric purity required for pharmaceutical applications, supporting the seamless synthesis of Ramelteon.

For companies in the process of developing or manufacturing Ramelteon, securing a consistent and high-quality supply of this intermediate is a strategic imperative. By partnering with experienced manufacturers in China, you can gain access to competitive pricing and a reliable source for this crucial chemical.

Conclusion: Securing Your Supply Chain

Procuring (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine requires careful consideration of product specifications, supplier reliability, and pricing. As a dedicated manufacturer and supplier of pharmaceutical intermediates, we are committed to providing the high-purity materials that drive successful drug development and manufacturing. Whether you are a research scientist exploring new drug candidates or a procurement manager ensuring stable supply, we invite you to request a quote or contact us to learn more about how we can meet your needs for this essential chemical.