For professionals in the chemical and pharmaceutical sectors, a thorough understanding of the materials they work with is crucial for both process efficiency and safety. 3,4-Dihydroxy-5-Nitrobenzaldehyde (CAS 116313-85-0) is a compound that plays a significant role as a pharmaceutical intermediate, particularly in the synthesis of drugs like Entacapone. This article aims to provide a comprehensive overview of its properties, safety considerations, and best practices for handling.

Chemical Identity and Key Properties

3,4-Dihydroxy-5-Nitrobenzaldehyde, with the molecular formula C7H5NO5, is an aromatic organic compound. It typically appears as a white to yellow crystalline powder. The molecule features a benzaldehyde core substituted with two hydroxyl (-OH) groups and a nitro (-NO2) group. Its molecular weight is approximately 183.12 g/mol. The presence of these functional groups dictates its chemical behavior and solubility.

Key physicochemical properties include:

  • Appearance: White to yellow crystalline powder.
  • Purity: Commonly supplied with assays of ≥99.0%, which is critical for pharmaceutical applications.
  • Melting Point: Reported around 147-149°C, indicating it is a solid at room temperature.
  • Solubility: Soluble in polar organic solvents like DMSO, which is common for molecules with hydroxyl groups.

Safety Information and Handling Precautions

As with many chemical compounds, especially those containing nitro groups, safety is a paramount concern. While specific hazard classifications can vary by supplier and region, general precautions should always be observed:

  • Irritancy: The compound may cause skin and eye irritation. Appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats should always be worn when handling.
  • Inhalation: Avoid breathing dust. Handling should be done in a well-ventilated area or under a fume hood.
  • Storage: It is typically recommended to store 3,4-Dihydroxy-5-Nitrobenzaldehyde in a cool, dry place, away from direct light and heat, in a well-closed container. This helps maintain its stability and prevent degradation.
  • Disposal: Chemical waste should be disposed of in accordance with local, regional, and national regulations. Consult the Material Safety Data Sheet (MSDS) for specific disposal guidelines.

Applications in the Pharmaceutical Industry

The primary application of 3,4-Dihydroxy-5-Nitrobenzaldehyde is as a critical intermediate in the synthesis of Entacapone. Entacapone is used to treat Parkinson's disease symptoms by inhibiting the enzyme catechol-O-methyltransferase (COMT), thus extending the effect of levodopa. The demand for high-purity 3,4-Dihydroxy-5-Nitrobenzaldehyde directly correlates with the production needs for Entacapone. Manufacturers and R&D scientists rely on this compound to build the complex molecular structure of the API.

Sourcing and Supply from Reputable Manufacturers

When purchasing 3,4-Dihydroxy-5-Nitrobenzaldehyde, it is imperative to select suppliers who can guarantee quality and provide essential documentation. As a dedicated manufacturer and supplier, we ensure our product meets rigorous purity standards and is accompanied by relevant safety and quality data. We provide this compound in various packaging sizes to suit different scales of research and industrial production. Understanding the handling requirements and having access to a reliable supplier like ourselves is key to successful project execution.

By prioritizing safety, understanding the chemical properties, and sourcing from trusted manufacturers, professionals can effectively utilize 3,4-Dihydroxy-5-Nitrobenzaldehyde in their synthesis projects, contributing to advancements in pharmaceutical development.