In the intricate world of pharmaceutical synthesis, specific chemical intermediates act as the bedrock upon which life-saving medications are built. (R)-(+)-3-Butyn-2-ol, designated by CAS 42969-65-3 and also known as (2R)-but-3-yn-2-ol or (R)-(+)-3-Butyn-2-ol, is one such vital compound. This colorless transparent liquid is a highly valued chiral alcohol, indispensable for the creation of complex organic molecules, most notably the pharmaceutical Vorapaxar Sulfate.

The chemical identity of (R)-(+)-3-Butyn-2-ol is defined by its formula C4H6O and a molecular weight of 70.090. Its significance in synthesis stems from its chiral center and the presence of both a reactive alkyne and a hydroxyl group. These attributes make it an ideal starting material for stereoselective reactions, ensuring that the final pharmaceutical product possesses the correct three-dimensional structure, which is crucial for its therapeutic action. Manufacturers typically offer this intermediate with an assay of ≥98.0%, guaranteeing the high purity required for pharmaceutical applications.

The primary driver for the demand for (R)-(+)-3-Butyn-2-ol is its role in the synthesis of Vorapaxar Sulfate (CAS: 705260-08-8). Vorapaxar Sulfate is an important anticoagulant medication used to prevent cardiovascular events such as heart attacks and strokes. The synthesis of Vorapaxar Sulfate is a multi-step process where the precise structural integrity provided by (R)-(+)-3-Butyn-2-ol is paramount. Reliable suppliers of this compound in China ensure that the global pharmaceutical industry has consistent access to this essential building block.

The physical properties of (R)-(+)-3-Butyn-2-ol, including its boiling point of 108-111 ºC and a flash point of 10 ºC, highlight the need for careful storage and handling. It is classified as flammable, and therefore, it must be stored in cool, well-ventilated environments away from heat and ignition sources. Companies like NINGBO INNO PHARMCHEM CO.,LTD. adhere to strict quality and safety protocols, ensuring the integrity of the product from manufacturing to delivery. For businesses seeking to buy (R)-(+)-3-Butyn-2-ol, understanding its precise role in pharmaceutical synthesis is key to appreciating its value.

The ongoing advancements in medicinal chemistry continue to underscore the importance of readily available, high-quality chiral intermediates. (R)-(+)-3-Butyn-2-ol, supplied by dedicated manufacturers in China, plays a critical part in this ecosystem, enabling the development and production of vital pharmaceuticals that improve global health.