In the complex and demanding field of pharmaceutical manufacturing, the identification and utilization of precise chemical building blocks are crucial for developing effective and safe medications. (R)-(+)-3-Butyn-2-ol, identified by CAS 42969-65-3, is a prime example of such a compound. This chiral alcohol, also known by its synonyms (2R)-but-3-yn-2-ol and (R)-(+)-3-Butyn-2-ol, is a colorless transparent liquid that plays a pivotal role in the synthesis of critical pharmaceutical intermediates.

The chemical essence of (R)-(+)-3-Butyn-2-ol lies in its unique molecular structure. With the formula C4H6O and a molecular weight of 70.090, it possesses both a reactive alkyne functional group and a chiral center. This combination makes it an ideal candidate for stereoselective synthesis, a highly specialized area of organic chemistry essential for producing enantiomerically pure drugs. The high purity, typically ≥98.0%, ensures that it meets the stringent requirements of the pharmaceutical industry, where even trace impurities can have significant consequences.

The most notable application of (R)-(+)-3-Butyn-2-ol is its indispensable role in the synthesis of Vorapaxar Sulfate (CAS: 705260-08-8). Vorapaxar Sulfate is a significant pharmaceutical agent used in antiplatelet therapy to prevent thrombotic events, particularly in patients with a history of cardiovascular issues. The meticulous synthesis of Vorapaxar Sulfate relies heavily on the predictable reactivity and defined stereochemistry of (R)-(+)-3-Butyn-2-ol. This reliance makes reliable sourcing from experienced manufacturers, such as those in China, a critical factor for pharmaceutical companies.

The physical characteristics of (R)-(+)-3-Butyn-2-ol, including its boiling point (108-111 ºC) and flash point (10 ºC), necessitate careful handling and storage. Its flammability requires storage in cool, well-ventilated areas away from any potential ignition sources. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. adhere to strict protocols to ensure product quality and safety throughout the supply chain. For any entity looking to buy (R)-(+)-3-Butyn-2-ol, understanding these handling requirements and the compound's specific utility is essential for successful integration into synthesis processes.

As the pharmaceutical landscape evolves, the demand for high-quality, specialized chiral intermediates like (R)-(+)-3-Butyn-2-ol remains strong. The manufacturing prowess found in China ensures that this vital chemical building block is available to support the development and production of advanced therapeutic agents worldwide.