For procurement managers and R&D scientists in the pharmaceutical and fine chemical sectors, sourcing critical intermediates like 6-Bromo-4-chloropyrido[2,3-d]pyrimidine (CAS: 1215787-31-7) requires a strategic approach. As a specialized heterocyclic compound, its availability, purity, and consistent supply chain are paramount. This article aims to guide you through the process of purchasing this valuable building block, focusing on obtaining it from reputable manufacturers and suppliers, particularly within China, where much of the global fine chemical production is concentrated.

Understanding the Product: 6-Bromo-4-chloropyrido[2,3-d]pyrimidine is a compound with a distinct pyrido[2,3-d]pyrimidine core, featuring bromine and chlorine substituents. Its CAS number, 1215787-31-7, is your primary identifier for accurate sourcing. Key physical properties, such as its appearance as a white to yellow solid and a melting point range of 152-154 °C, are important indicators of its quality and form. For chemists, knowing its molecular formula (C7H3BrClN3) and molecular weight (244.48) is crucial for reaction stoichiometry and planning.

The Manufacturing Process and Quality Assurance: The synthesis of this intermediate typically involves reacting 6-bromopyrido[2,3-d]pyrimidin-4(1H)-one with phosphorus oxychloride (POCl3). The resulting product is often purified through recrystallization, yielding a solid with reported purities often around 95%. When you buy this chemical, it's essential to inquire about the manufacturer's quality control processes. Reputable suppliers will provide Certificates of Analysis (CoA) detailing purity, analytical methods used (like HPLC or NMR), and potentially other characterization data. This ensures that what you purchase meets your project's stringent requirements.

Sourcing from China: China has emerged as a global hub for chemical manufacturing, offering competitive pricing and a vast array of products. When looking to buy 6-Bromo-4-chloropyrido[2,3-d]pyrimidine from a Chinese manufacturer or supplier, diligence is key. Look for companies with established reputations, clear product specifications, and responsive customer service. Websites like ChemicalBook, Alfa Chemical, and Amadis Chemical often list numerous suppliers, providing contact information and product details. Requesting a free sample is a common practice to verify product quality before committing to larger orders. The price can vary significantly based on the supplier, quantity, and purity, so comparing quotes from multiple manufacturers is advisable.

Key Considerations for Procurement: When you decide to purchase 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, consider the following:

  • Quantity: Are you looking for research quantities (grams) or bulk for pilot scale production (kilograms)? Pricing structures often change significantly with scale.
  • Lead Time: Understand the supplier's production and shipping lead times to ensure your project timelines are met.
  • Purity Requirements: Confirm that the offered purity aligns with your application's needs. Higher purity might command a higher price.
  • Technical Support: A good supplier will offer technical support to answer questions about synthesis, applications, or handling.

In conclusion, procuring 6-Bromo-4-chloropyrido[2,3-d]pyrimidine from a reliable manufacturer in China involves careful research and due diligence. By focusing on product specifications, quality assurance, and supplier reputation, you can secure this vital intermediate efficiently and cost-effectively. If you're seeking a trusted supplier for your chemical needs, consider manufacturers who demonstrate transparency and a commitment to quality, ensuring your research and development projects progress smoothly.