In the continuous effort to improve patient outcomes in cancer treatment, innovative chemical compounds play a pivotal role. Gimeracil, identified by its CAS number 103766-25-2, stands out as a crucial pharmaceutical intermediate, particularly for its ability to inhibit dihydropyrimidine dehydrogenase (DPD). As a prominent manufacturer and supplier of specialized chemicals in China, we are dedicated to providing researchers and pharmaceutical companies with access to high-quality Gimeracil.

Gimeracil's primary mechanism of action involves the inhibition of DPD, an enzyme that plays a crucial role in the metabolic pathway of pyrimidine-based drugs. Many standard chemotherapy agents, including the widely used 5-fluorouracil (5-FU), are pyrimidine analogs. DPD rapidly metabolizes these drugs, reducing their therapeutic effectiveness. By inhibiting DPD, Gimeracil effectively prolongs the presence of 5-FU and similar drugs in the bloodstream. This extended circulation allows for a more sustained and potent action against cancer cells, leading to improved treatment responses.

Furthermore, Gimeracil has demonstrated value as a radiosensitizer. This property means it can enhance the effectiveness of radiation therapy. It achieves this by interfering with the DNA repair mechanisms that cancer cells employ to recover from radiation-induced damage. Specifically, Gimeracil inhibits homologous recombination, a key pathway for repairing double-strand breaks in DNA. By compromising these repair processes, Gimeracil makes cancer cells more susceptible to radiation-induced cell death, creating a synergistic effect when used in combination therapies.

For professionals involved in pharmaceutical research and development, sourcing Gimeracil necessitates a focus on purity and reliability. We are a leading manufacturer in China committed to producing Gimeracil that meets stringent quality specifications, typically with a purity of 99% or greater. Our commitment to excellence ensures that our Gimeracil is a trustworthy component for your research and formulation needs. We provide the quality you expect when you buy Gimeracil.

As a trusted supplier, we offer competitive pricing, especially for bulk purchases, making it easier for research institutions and pharmaceutical companies to access this vital compound. Our robust supply chain and efficient logistics ensure timely delivery worldwide. We understand the critical nature of pharmaceutical intermediates and strive to provide exceptional service, including comprehensive product documentation like Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS). Partnering with us means securing a dependable supply of Gimeracil from China.

We encourage all interested researchers and procurement managers to contact us for detailed information on Gimeracil (CAS 103766-25-2). Whether you require it for preclinical studies, clinical trials, or formulation development, our team is prepared to assist you with your specific requirements. We are dedicated to supporting advancements in cancer care by providing high-quality pharmaceutical intermediates and responsive customer support.

In summary, Gimeracil (CAS 103766-25-2) is a significant compound in modern oncology, instrumental in enhancing the efficacy of chemotherapy and radiation. Its role as a DPD inhibitor and radiosensitizer makes it an indispensable tool for improving patient outcomes. We, as a premier Chinese manufacturer and supplier, are committed to delivering Gimeracil of the highest quality to support groundbreaking research and therapeutic development. Contact us today to buy Gimeracil and advance your mission in fighting cancer.