Advancements in neuroscience are often driven by the development and application of precise molecular probes. Among these, peptides that modulate ion channel activity are crucial for understanding complex neurological functions and disorders. PE 22-28, a potent inhibitor of TREK-1 channels, has emerged as a significant research tool, particularly in the study of depression and neuroprotection. This article delves into the scientific value of PE 22-28, its applications, and how researchers can reliably source this essential peptide.

PE 22-28, with its identified CAS number 1801959-12-5, is a peptide that specifically targets and inhibits TREK-1 channels. TREK-1 channels are integral to neuronal excitability and are implicated in various physiological processes, including pain signaling and mood regulation. The high potency of PE 22-28, reflected in its IC50 value of 0.12 nM, allows for a detailed and accurate exploration of TREK-1's role in these processes. This specificity is invaluable for researchers seeking to dissect the molecular pathways involved in neurological conditions.

The research applications for PE 22-28 are substantial, especially within the field of depression research. Scientific literature suggests that PE 22-28 exhibits antidepressant-like effects in preclinical models, making it a key compound for investigating novel therapeutic targets for mood disorders. Beyond its impact on mood, PE 22-28 also plays a role in neuroprotection. Studies have shown its capacity to reduce cellular damage and promote neurogenesis, particularly in contexts related to ischemia. This dual utility makes PE 22-28 a versatile peptide for researchers exploring both the etiology of neurological diseases and potential recovery mechanisms.

For researchers in need of PE 22-28, identifying a trusted manufacturer and supplier is critical to ensure product quality and experimental reliability. We are a leading provider of high-purity research chemicals, including PE 22-28, with a commitment to delivering products that typically exceed 99% purity. Access to detailed technical data, such as Certificates of Analysis (CoA), is essential for verifying product specifications and suitability for specific research protocols. We encourage researchers to buy PE 22-28 from suppliers who demonstrate transparency in their manufacturing and quality control processes.

The availability of PE 22-28 empowers scientific exploration into the mechanisms of depression, pain, and neuronal health. Its application in various experimental settings, from in vitro cellular assays to in vivo animal models, underscores its importance. We offer competitive pricing and flexible quantities, catering to the diverse needs of academic institutions, biotech companies, and pharmaceutical research divisions. Inquiries regarding bulk purchases or specific product inquiries are welcomed to ensure seamless procurement.

In conclusion, PE 22-28 represents a significant advancement in the availability of precise research tools for neuroscience. Its role as a potent TREK-1 inhibitor, coupled with its demonstrated effects in depression research and neuroprotection, makes it indispensable for current scientific endeavors. We are dedicated to supporting these efforts by providing high-quality PE 22-28 and invite researchers to partner with us for their critical peptide needs.