For scientists engaged in medicinal chemistry and oncology research, a thorough understanding of key molecular precursors is essential. 10-Deacetylbaccatin III (CAS 32981-86-5) is a prime example – a natural product that serves as a vital cornerstone in the development of taxane-based chemotherapies. As a specialized manufacturer and supplier, we are dedicated to providing researchers with the high-purity material and scientific insights they need.

Chemical Structure and Physical Properties

10-Deacetylbaccatin III is a complex diterpenoid characterized by its intricate polycyclic structure derived from yew trees. Its molecular formula is C29H36O10, and its molecular weight is approximately 544.59 g/mol. As a high-purity compound, it typically presents as a white to off-white crystalline powder, making it suitable for precise chemical synthesis. Researchers often specify a minimum purity level, commonly assessed by HPLC, to ensure the reliability of their experimental outcomes. For those looking to buy 10-Deacetylbaccatin III for research purposes, understanding these specifications is crucial.

Biological Activity and Mechanism of Action

While 10-Deacetylbaccatin III itself is not directly administered as a therapeutic agent, its biological significance lies in its role as a precursor. It is the key intermediate that enables the semi-synthesis of paclitaxel and docetaxel. These resultant drugs exert their anti-cancer effects by interacting with microtubules, the structural components of the cell's cytoskeleton. Specifically, taxanes bind to tubulin and promote the assembly of stable microtubules, preventing their normal disassembly. This process disrupts the dynamic equilibrium essential for cell division, ultimately leading to apoptosis in rapidly dividing cancer cells. Research into the precise interactions and structure-activity relationships of taxanes often begins with high-quality 10-Deacetylbaccatin III.

Applications in Scientific Research and Drug Development

The utility of 10-Deacetylbaccatin III extends across several research domains:

  • Oncology Drug Discovery: It is fundamental for the synthesis of new taxane analogs, exploring variations that might overcome drug resistance or reduce side effects. Researchers can order 10-Deacetylbaccatin III to facilitate these innovative projects.
  • Medicinal Chemistry: Its complex structure makes it an excellent substrate for exploring novel synthetic methodologies and chemical transformations.
  • Pharmacological Studies: Researchers use it to synthesize specific taxane derivatives for in-depth pharmacological investigations, including mechanism-of-action studies and preclinical evaluations.
  • Natural Product Chemistry: It serves as a subject for studying extraction, purification, and the biosynthesis of complex natural products.

As a dedicated 10-Deacetylbaccatin III manufacturer, we are committed to supporting the scientific community. By providing a reliable source of this essential precursor, we empower researchers to push the boundaries of cancer treatment and medicinal chemistry. Connect with us to source your high-purity 10-Deacetylbaccatin III and advance your research endeavors.