For professionals engaged in peptide synthesis, particularly those utilizing the widely adopted Fmoc (9-fluorenylmethyloxycarbonyl) solid-phase peptide synthesis (SPPS) strategy, the choice of amino acid derivatives is paramount. Fmoc-L-Arg(Pbf)-OH (CAS 154445-77-9) is a critical component for incorporating arginine, an amino acid known for its complex side chain that requires careful protection to ensure successful peptide assembly.

As a key building block in peptide chemistry, sourcing high-quality Fmoc-L-Arg(Pbf)-OH is crucial for achieving reproducible and pure peptide products. This guide aims to equip researchers and manufacturers with the knowledge to effectively source this essential reagent. If you are looking to buy Fmoc-L-Arg(Pbf)-OH, partnering with a reputable supplier is key to success.

The Critical Role of Pbf Protection for Arginine

Arginine's guanidino group is highly nucleophilic and can undergo a variety of undesired reactions during SPPS, including side-chain acylation and alkylation. These reactions can significantly reduce the yield and purity of the final peptide. The Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group serves as an effective protecting group for this side chain. It offers:

  • Stability: The Pbf group is stable under the basic conditions used to remove the Fmoc protecting group, ensuring that the arginine side chain remains protected throughout the synthesis cycles.
  • Efficient Cleavage: It is readily cleaved under acidic conditions, typically within a TFA-based cleavage cocktail, which is used in the final step to release the synthesized peptide from the solid support and remove all side-chain protecting groups.

Why Choose a Dedicated Manufacturer?

When you are ready to purchase Fmoc-Arg(Pbf)-OH, selecting a reliable manufacturer like us offers distinct advantages:

  • Guaranteed Purity: We provide Fmoc-L-Arg(Pbf)-OH with a guaranteed high purity (≥99.0%). This is essential for demanding applications in pharmaceutical development and scientific research, ensuring that your peptide synthesis results are accurate and reproducible.
  • Consistent Quality: Our manufacturing processes are designed to ensure batch-to-batch consistency, which is vital for scaled-up production and validation studies.
  • Competitive Pricing: We strive to offer competitive prices for our high-quality peptide synthesis reagents, understanding the budgetary constraints in research and manufacturing. Bulk order discounts are available.
  • Technical Expertise: As specialists, we can provide detailed technical information and support for our products, assisting you in selecting the best reagents for your specific synthesis needs.

Applications of Fmoc-L-Arg(Pbf)-OH

This protected arginine derivative is indispensable for:

  • Solid-Phase Peptide Synthesis (SPPS): A standard reagent in Fmoc SPPS for constructing peptides containing arginine residues, crucial for a wide range of biological functions.
  • Therapeutic Peptide Manufacturing: Essential for producing peptide drugs and drug candidates that rely on arginine for their activity, stability, or delivery.
  • Custom Peptide Synthesis Services: Widely used by contract research organizations (CROs) and custom synthesis providers to fulfill client orders for complex peptides.
  • Biotechnology Research: Employed in research laboratories for developing novel peptide probes, diagnostic agents, and biomaterials.

We are a trusted supplier dedicated to advancing peptide science by providing high-quality reagents. We invite you to contact us to request a quote for Fmoc-L-Arg(Pbf)-OH and discuss your bulk procurement needs.