Carboxyatractyloside (C-ATR, CAS 35988-42-2) is more than just a chemical compound; it's a sophisticated molecular tool that unlocks deeper insights into cellular energy metabolism and the intricate pathways of cell death. For biochemists, pharmacologists, and drug discovery scientists, understanding and utilizing C-ATR can be pivotal for their research endeavors. This article explores its significance and how to acquire it for laboratory use.

At its core, Carboxyatractyloside is renowned for its potent and specific inhibition of the mitochondrial ADP/ATP translocase (ANT). This enzyme acts as a gatekeeper, controlling the flux of adenine nucleotides between the cytoplasm and the mitochondrial matrix. Disrupting this crucial transport mechanism with C-ATR allows researchers to meticulously study the consequences of impaired ATP production on various cellular functions. This includes investigations into mitochondrial efficiency, oxidative phosphorylation, and the overall bioenergetics of different cell types.

The compound's ability to induce mitochondrial membrane permeabilization also positions it as a key player in apoptosis research. By triggering the release of cytochrome c and other pro-apoptotic factors from mitochondria, C-ATR provides a direct route to study the intrinsic pathway of programmed cell death. This is invaluable for understanding diseases where apoptosis is dysregulated, such as cancer (where it may be inhibited) or neurodegenerative conditions (where it may be excessive). Researchers looking to buy Carboxyatractyloside for these studies are seeking a reagent that can reliably initiate these cellular events.

For those engaged in drug discovery, Carboxyatractyloside serves as a critical reference compound and a tool for validating new drug targets. By understanding how ANT inhibitors affect cellular processes, scientists can design molecules that modulate mitochondrial function or apoptosis for therapeutic benefit. When procuring this compound, it is essential to partner with reliable manufacturers and suppliers, often found in regions like China, known for their expertise in producing high-purity fine chemicals. The availability of competitive pricing from these sources further supports budget-conscious research initiatives.

When sourcing Carboxyatractyloside (CAS 35988-42-2), buyers should prioritize suppliers offering high purity (e.g., >95%) and providing comprehensive technical documentation, such as a Certificate of Analysis. The molecular formula (C31H46O18S2) and molecular weight (approx. 847.0) are also key identifiers. Inquiring about bulk price and lead times is standard practice for research institutions planning extensive studies or pilot drug discovery programs.

In conclusion, Carboxyatractyloside stands as a cornerstone reagent in biochemical research and drug discovery. Its targeted action on the ADP/ATP translocase and its role in apoptosis make it indispensable for a wide array of studies. By strategically sourcing this compound from reputable suppliers, researchers can ensure the integrity of their experiments and accelerate the pace of scientific innovation.