For pharmaceutical companies focused on oncology, securing a reliable supply of high-quality intermediates is paramount. One such crucial intermediate is 1,2,3-Triacetyl-5-deoxy-D-ribose (CAS 62211-93-2), a cornerstone in the synthesis pathway of Capecitabine, a widely used oral chemotherapeutic agent. Understanding the market for this vital compound, including where to buy it and what to look for in a supplier, is essential for procurement managers and R&D scientists.

The Significance of 1,2,3-Triacetyl-5-deoxy-D-ribose in Capecitabine Synthesis

Capecitabine is a prodrug that is converted into 5-fluorouracil (5-FU) within the body, targeting cancer cells more selectively. The synthesis of Capecitabine involves several steps, and 1,2,3-Triacetyl-5-deoxy-D-ribose serves as a key chiral building block. Its precise structure and high purity are critical to ensuring the efficacy and safety of the final Active Pharmaceutical Ingredient (API). Impurities in this intermediate can lead to the formation of unwanted byproducts, complicating purification and potentially affecting the final drug's therapeutic profile.

What to Look for When Buying This Intermediate

When you need to buy 1,2,3-Triacetyl-5-deoxy-D-ribose, several factors should guide your selection of a manufacturer or supplier:

  • Purity: Look for a minimum purity of 98% (GC). High purity minimizes downstream purification challenges and ensures product quality.
  • CAS Number Verification: Always confirm the CAS number is 62211-93-2 to ensure you are sourcing the correct compound.
  • Manufacturer Reputation: Partner with established manufacturers and suppliers who have a proven track record in producing pharmaceutical intermediates. Reliability in supply and adherence to quality standards are non-negotiable.
  • Documentation: Ensure the supplier can provide necessary documentation such as Certificates of Analysis (CoA), and potentially support for regulatory filings.
  • Pricing: While quality is key, competitive pricing is also important. Comparing quotes from multiple reputable suppliers can help secure cost-effective procurement.

Global Sourcing Landscape: Manufacturers and Suppliers

The global market offers numerous options for sourcing CAS 62211-93-2. Many reputable manufacturers and suppliers are based in China, offering competitive pricing and a wide range of quantities, from research-scale grams to industrial tons. When searching for a 1,2,3-Triacetyl-5-deoxy-D-ribose supplier in China, focus on companies that specialize in fine chemicals and pharmaceutical intermediates. These suppliers often have robust quality management systems and can provide the necessary technical support.

Navigating Procurement: Tips for Success

To streamline your procurement process, consider the following:

  • Request Samples: Before placing a bulk order, request samples to verify quality and suitability for your specific synthesis process.
  • Inquire About Lead Times: Understand the production and delivery timelines to ensure they align with your project schedule.
  • Build Supplier Relationships: Developing strong relationships with key suppliers can lead to better service, consistent supply, and potentially more favorable terms over time.

In conclusion, sourcing 1,2,3-Triacetyl-5-deoxy-D-ribose requires careful consideration of purity, supplier reliability, and price. By partnering with experienced manufacturers and suppliers, pharmaceutical companies can ensure the efficient and successful synthesis of Capecitabine, ultimately contributing to better patient outcomes.