For procurement managers and R&D scientists in the pharmaceutical industry, sourcing high-quality Active Pharmaceutical Ingredients (APIs) and their intermediates is paramount. The efficacy and safety of the final drug product, such as Febuxostat, depend heavily on the purity and consistency of the starting materials. This article delves into the critical aspects of sourcing a key Febuxostat intermediate: Ethyl 2-[4-(2-methylpropoxy)-3-nitrophenyl]-1,3-thiazole-5-carboxylate (CAS: 144060-93-5). Understanding its specifications and the role of reliable manufacturers is crucial for successful procurement and production.

Understanding the Intermediate: Ethyl 2-[4-(2-methylpropoxy)-3-nitrophenyl]-1,3-thiazole-5-carboxylate

This specific chemical compound serves as a vital building block in the multi-step synthesis of Febuxostat, a widely prescribed medication for managing hyperuricemia and gout. Its chemical structure, characterized by a thiazole ring and specific functional groups, is precisely engineered to facilitate the subsequent reactions leading to the final API. As a leading manufacturer and supplier, we understand the stringent requirements for this intermediate, ensuring it meets assay specifications of ≥98.0% and is presented as a white to off-white crystalline powder. This level of purity is non-negotiable for pharmaceutical applications, as impurities can significantly impact the downstream synthesis and the quality of the final Febuxostat product.

The Importance of Quality and Specification

When you are looking to buy this critical intermediate, prioritizing quality and adherence to specifications is essential. Factors to consider include:

  • Purity Assay: Always verify the minimum purity level. For pharmaceutical intermediates, a high assay (e.g., ≥98.0%) is critical.
  • Physical Characteristics: Consistency in appearance (e.g., white to off-white crystalline powder) and particle size can influence reaction kinetics and ease of handling.
  • Storage and Handling: Proper packaging (e.g., 25 kg drums) and recommended storage conditions are vital to maintain product integrity.
  • Manufacturing Standards: For GMP-compliant processes, it's beneficial to partner with manufacturers who follow rigorous quality management systems.

Finding a Reliable Manufacturer and Supplier in China

China has emerged as a global hub for chemical manufacturing, offering a vast array of intermediates and APIs. However, for critical pharmaceutical components like Febuxostat intermediates, selecting the right supplier is paramount. When evaluating potential manufacturers, consider their:

  • Track Record: Look for established companies with a proven history in producing pharmaceutical intermediates.
  • Quality Control: Ensure they have robust in-house QC/QA processes and can provide Certificates of Analysis (CoA) with each batch.
  • Technical Support: A responsive supplier that can offer technical data and support can be invaluable.
  • Regulatory Compliance: While not always mandatory for early-stage intermediates, an understanding of GMP principles is a good indicator of quality.
  • Pricing and Lead Times: Balancing cost-effectiveness with reliable delivery schedules is key for efficient supply chain management.

Why Choose Us as Your Supplier?

As a dedicated manufacturer and supplier based in China, we pride ourselves on delivering high-purity Ethyl 2-[4-(2-methylpropoxy)-3-nitrophenyl]-1,3-thiazole-5-carboxylate. Our commitment extends beyond simply supplying a chemical; we aim to be a trusted partner in your drug development and manufacturing journey. We understand the market's need for dependable sources for Febuxostat intermediates and strive to provide competitive pricing without compromising on quality. Whether you are in the research phase or scaling up for commercial production, we are equipped to meet your demands. When you need to buy this essential intermediate, consider us your go-to supplier for quality, reliability, and value.

For procurement inquiries or to request a quote for Ethyl 2-[4-(2-methylpropoxy)-3-nitrophenyl]-1,3-thiazole-5-carboxylate, please contact us. We are ready to support your pharmaceutical manufacturing needs.