For procurement professionals and research scientists in the pharmaceutical and chemical industries, identifying reliable sources for key intermediates is a critical operational task. 4-Chloro-7-methoxyquinoline-6-carboxamide (CAS: 417721-36-9) is one such compound, primarily recognized for its indispensable role in the synthesis of Lenvatinib, a significant anti-cancer drug. This guide aims to equip buyers with the knowledge to confidently source this high-value intermediate, focusing on quality, specifications, and finding reputable manufacturers and suppliers.

The chemical profile of 4-Chloro-7-methoxyquinoline-6-carboxamide is well-defined, with a molecular formula of C11H9ClN2O2 and a molecular weight of approximately 236.65 g/mol. As an off-white to light yellow solid powder, its appearance is a preliminary indicator of its physical state. The most crucial specification for its application in pharmaceutical synthesis is purity, typically sought at or above 98% via High-Performance Liquid Chromatography (HPLC). Buyers should always request a detailed Certificate of Analysis (CoA) from potential suppliers to verify purity, identify impurities, and confirm adherence to established standards.

The primary driver for the demand of 4-Chloro-7-methoxyquinoline-6-carboxamide is its direct use as a building block in the chemical synthesis of Lenvatinib. Lenvatinib is a targeted therapy used to treat advanced differentiated thyroid cancer, unresectable hepatocellular carcinoma, and advanced renal cell carcinoma. Consequently, any interruption in the supply of this intermediate can have significant repercussions on the production of this vital medication. When you decide to buy this chemical, ensuring the supplier has a robust manufacturing capacity and a stable track record is paramount.

When evaluating suppliers, consider their geographical location and manufacturing expertise. Many leading manufacturers and suppliers of pharmaceutical intermediates are located in China, offering competitive pricing and large-scale production capabilities. However, it is essential to vet these suppliers thoroughly. Look for companies that demonstrate strong quality control systems, clear communication channels, and a willingness to provide samples for evaluation. Understanding their packaging and storage recommendations—often requiring storage in sealed containers at cool, dry places, protected from light and moisture—is also important for maintaining product integrity after purchase.

For bulk purchases, engaging in direct dialogue with manufacturers is often beneficial. This allows for discussions regarding pricing, lead times, and any specific quality requirements. Requesting a quotation that includes all relevant specifications, packaging details, and delivery terms is standard practice. By focusing on these key aspects and partnering with a reputable manufacturer and supplier, procurement professionals can secure a reliable supply of 4-Chloro-7-methoxyquinoline-6-carboxamide, thereby ensuring the continued production of Lenvatinib and contributing to patient care worldwide.