The field of peptide synthesis is continually advancing, driven by the development of new therapeutics and research tools. At the heart of these advancements is the availability of high-quality building blocks. Nalpha-Fmoc-Ndelta-Boc-L-ornithine, known by its CAS number 109425-55-0 and often abbreviated as Fmoc-Orn(Boc)-OH, is one such critical component. This article focuses on why sourcing this specific protected amino acid derivative is vital for your peptide synthesis needs and how to find a reliable manufacturer and supplier.

The Significance of Fmoc-Orn(Boc)-OH in Peptide Synthesis

Fmoc-Orn(Boc)-OH is an essential derivative of the amino acid ornithine, distinguished by the presence of two commonly used protecting groups: Fmoc and Boc. The Fmoc group, attached to the alpha-amino group, is labile to basic conditions, allowing for its removal during stepwise peptide chain elongation. The Boc group, protecting the side-chain amine, offers orthogonal protection, meaning it can be removed under acidic conditions without affecting the Fmoc group or the peptide backbone. This strategic protection scheme is fundamental to the Fmoc/tBu solid-phase peptide synthesis strategy, which is widely adopted for its efficiency and reliability.

The molecule's structure (C25H30N2O6) and its physical form (typically a white powder) are important, but its purity is paramount. A minimum purity of 95-98%, often verified by HPLC, is generally required for successful and reproducible peptide synthesis. Impurities can lead to truncated peptides, deletions, or other undesired side products, significantly impacting experimental outcomes and the quality of the final peptide product.

Where to Buy Fmoc-Orn(Boc)-OH: Choosing a Reliable Supplier

For researchers and procurement specialists in the pharmaceutical, biotechnology, and fine chemical industries, finding a consistent and trustworthy source for Fmoc-Orn(Boc)-OH is crucial. When searching for a supplier, consider the following:

  • Manufacturer Reputation: Opt for manufacturers with a proven track record in producing high-purity amino acid derivatives.
  • Product Specifications: Ensure the product details, including CAS number (109425-55-0), molecular formula, and purity levels, meet your project requirements.
  • Certificates of Analysis (CoA): A reliable supplier will provide a detailed CoA with each batch, confirming purity and characterization data.
  • Supply Chain Stability: Given the critical nature of these intermediates, a stable and reliable supply chain is essential to avoid research or production delays.
  • Pricing and Accessibility: While quality is key, competitive pricing from manufacturers in regions like China can offer significant cost advantages for bulk purchases.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a leading manufacturer and supplier of essential pharmaceutical intermediates. We understand the importance of high-purity Fmoc-Orn(Boc)-OH for your peptide synthesis and drug discovery endeavors. We encourage you to reach out to us for a quote and sample to assess our product quality and service. Secure your supply chain with a partner dedicated to your success.