In the rigorous process of pharmaceutical formulation and development, the selection of high-quality intermediates is a critical step. Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid, identified by its CAS number 190190-48-8, is a specialized chemical that offers significant advantages for formulators and synthetic chemists alike. This article outlines its value and provides guidance on sourcing this essential compound.

The Strategic Importance of Boc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid

This compound is a synthetically useful building block primarily due to its unique structural attributes:

  • Boc-Protected Amine: The tert-butyloxycarbonyl (Boc) group is a widely used protecting group in organic synthesis. It safeguards the amine functionality during various reaction steps, allowing for precise manipulation of other parts of the molecule. Its facile removal under mild acidic conditions is a key advantage in multi-step syntheses, common in the development of complex drug molecules.
  • Chiral Center: The presence of a defined stereocenter, specifically the (R)-configuration, is crucial for creating enantiomerically pure active pharmaceutical ingredients (APIs). Chirality plays a vital role in how drug molecules interact with biological targets, influencing efficacy and reducing potential side effects.
  • Benzothienyl Moiety: The benzothiophene ring structure is a common feature in many biologically active compounds. It can enhance lipophilicity, influence binding affinity to target proteins, and contribute to the overall pharmacokinetic profile of a drug candidate.

These combined features make Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid a valuable precursor for developing a wide range of pharmaceuticals.

Applications in Pharmaceutical Development

Formulators and synthetic chemists utilize this intermediate in several key areas:

  • API Synthesis: It serves as a core component in the synthesis of various APIs, where its specific structure contributes to the desired therapeutic outcome.
  • Peptidomimetics: It can be used to create molecules that mimic the structure and function of peptides, often leading to improved stability and bioavailability.
  • Drug Discovery Libraries: Its inclusion in compound libraries allows for the systematic exploration of chemical space in the search for new drug leads.

Sourcing and Purchasing Advice for Formulators

For pharmaceutical formulators needing to buy Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid, securing a consistent and high-quality supply is critical. When you search for a ‘Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid supplier,’ look for companies that can provide a Certificate of Analysis (COA) confirming purity (typically 97% or higher) and the correct stereochemistry. Manufacturers in China are often a strong source for such specialized chemicals, offering competitive pricing. Requesting a quote for the required quantities will help in budgeting and planning your synthesis projects. Ensure the supplier has robust quality control measures in place to meet pharmaceutical standards.

In summary, Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid is a strategically important intermediate for pharmaceutical innovation. By ensuring a reliable supply of this high-purity compound, formulators can efficiently develop new and effective therapeutic agents.