For procurement managers and R&D scientists in the pharmaceutical industry, sourcing reliable and high-quality raw materials is paramount. L-Norleucine (CAS 327-57-1) stands out as a critical amino acid derivative, frequently employed as a pharmaceutical intermediate in the synthesis of complex drug molecules. Understanding its specifications and identifying reputable suppliers is key to successful project execution.

Understanding L-Norleucine's Importance

L-Norleucine, also known as (S)-2-aminohexanoic acid, is a chiral building block characterized by its specific stereochemistry. Its chemical formula is C6H13NO2, with a molecular weight of 131.17. The purity specifications often cited, such as an assay of 98.5% to 101.0% and low levels of impurities like heavy metals and residue on ignition, underscore its suitability for demanding pharmaceutical applications. Its physical appearance is typically a white to off-white crystalline powder, making it convenient for handling and integration into various synthetic processes.

Key Specifications for Pharmaceutical Intermediates

When procuring L-Norleucine for pharmaceutical intermediate use, several specifications are critical:

  • Assay: A high assay (e.g., ≥97%) ensures minimal contamination, crucial for reproducible results in drug synthesis.
  • Chirality: As the (S)-isomer, L-Norleucine offers the specific stereochemical configuration often required for biological activity in target drug molecules.
  • Solubility and Stability: Its solubility in aqueous HCl and its stable crystalline form contribute to ease of use in laboratory and manufacturing settings.
  • Impurities: Low limits for loss on drying, residue on ignition, chloride, sulfate, heavy metals, iron, and arsenic are essential to prevent interference with sensitive reactions or contamination of the final API.

Where to Buy L-Norleucine: Supplier Considerations

For procurement professionals, identifying a dependable L-Norleucine manufacturer and supplier is a strategic decision. Factors to consider include:

  • Country of Origin: Many high-quality intermediates are sourced from manufacturers in China, known for their production capabilities and competitive pricing.
  • Purity and Documentation: Ensure the supplier provides a Certificate of Analysis (CoA) detailing all critical specifications.
  • Bulk Availability: For ongoing production needs, confirm the supplier's capacity to deliver in required quantities.
  • Pricing and Quotations: Requesting detailed quotations for bulk purchases can help in cost optimization.

When you need to buy L-Norleucine as a reliable pharmaceutical intermediate, look for suppliers who emphasize quality, consistency, and competitive pricing. Partnering with experienced manufacturers ensures you receive a product that meets rigorous industry standards, facilitating the successful development and production of your pharmaceutical products.