In the rigorous world of pharmaceutical manufacturing, the identification and control of impurities are as critical as the synthesis of the active pharmaceutical ingredient (API) itself. Impurities can arise from various stages of synthesis, degradation, or storage, and their presence can impact the safety and efficacy of a drug. Telbivudine, an antiviral medication, has associated impurities that require careful management. One such compound, often identified as Telbivudine Impurity 3 and designated by CAS number 141846-57-3, is 1-Chloro-2-deoxy-L-ribofuranose. Understanding this specific impurity is key for pharmaceutical quality control and research.

Telbivudine Impurity 3 (CAS 141846-57-3) is chemically known as 1-Chloro-2-deoxy-L-ribofuranose. Its significance lies in its potential presence during the synthesis of Telbivudine or related nucleoside analogs. As a synthetic intermediate, if not fully reacted or removed, it can persist in the final product, necessitating strict analytical methods for detection and quantification. Pharmaceutical companies rely on high-purity reference standards of such impurities to develop and validate analytical methods, ensuring that their final drug products meet stringent pharmacopoeial standards.

For companies involved in the production of Telbivudine or engaged in research on related nucleoside compounds, sourcing high-purity Telbivudine Impurity 3 (CAS 141846-57-3) is essential. Reputable chemical suppliers specializing in pharmaceutical intermediates and impurity standards offer this compound. When seeking to buy, it's vital to look for suppliers who can guarantee a high degree of purity, typically >99%, and provide comprehensive documentation, including certificates of analysis (CoA) detailing its identity, purity, and physical properties. This ensures that the reference material is reliable for analytical purposes.

The price of such specialized pharmaceutical impurities is influenced by factors like production complexity, purity levels, and order volume. For research quantities, the cost per gram might seem high, reflecting the specialized manufacturing and purification processes involved. However, for quality control and drug development, this investment is crucial. Manufacturers often offer bulk pricing for larger quantities needed for routine quality control in API production.

Global sourcing platforms and specialized chemical manufacturers are key avenues for obtaining Telbivudine Impurity 3. Companies looking for a reliable supplier in China can find numerous manufacturers that produce this intermediate. A proactive approach to supplier evaluation, including checking for ISO certifications and understanding their quality management systems, is recommended. This diligence ensures that the purchased impurity standard is accurate and consistent, thereby safeguarding the integrity of your pharmaceutical products.

In summary, Telbivudine Impurity 3 (CAS 141846-57-3), or 1-Chloro-2-deoxy-L-ribofuranose, is a critical compound in the quality control framework of pharmaceutical manufacturing. Its accurate identification and quantification are paramount for drug safety. Sourcing this high-purity intermediate from reliable manufacturers ensures that pharmaceutical companies can maintain the highest standards in their product development and manufacturing processes.