In the intricate world of chemical synthesis, specific molecular structures serve as crucial linchpins for creating complex and valuable compounds. One such compound, known scientifically as 1,2-O-Isopropylidene-3-benzyloxy-D-glucofuranose, and bearing the CAS number 22529-61-9, has garnered significant attention for its utility, particularly as a pharmaceutical intermediate. This article explores its chemical identity, key applications, and the importance of reliable sourcing for research and industrial purposes.

The chemical structure of 1,2-O-Isopropylidene-3-benzyloxy-D-glucofuranose, represented by the molecular formula C16H22O6 and a molecular weight of 310.34, reveals a protected form of D-glucofuranose. The presence of the isopropylidene group and the benzyl ether at the 3-O position are critical protecting groups that enable selective reactions in subsequent synthetic steps. Its physical form is typically an oil, often described as clear, colorless to yellow, with a density around 1.29 g/cm³. These characteristics are important for chemists handling and reacting the substance in various laboratory settings.

The primary and most well-documented application of 1,2-O-Isopropylidene-3-benzyloxy-D-glucofuranose is its role as a key intermediate in the synthesis of Fondaparinux Sodium. Fondaparinux is a synthetic analogue of the biologically active pentasaccharide fraction of heparin, widely used as an anticoagulant. The precise molecular architecture of this glucofuranose derivative makes it an indispensable precursor in the multi-step synthesis required to produce Fondaparinux Sodium, highlighting its importance in the pharmaceutical supply chain.

For laboratories and chemical manufacturers, securing a consistent supply of high-quality 1,2-O-Isopropylidene-3-benzyloxy-D-glucofuranose is crucial. Suppliers worldwide offer this compound, often with purity levels of 97% or higher. When seeking to buy this chemical, understanding the specifications, available quantities, and the reputation of the supplier is essential. The availability of this intermediate from manufacturers in China, for instance, provides global access for researchers and industrial clients aiming for efficient and cost-effective production processes. This enables further exploration and development within advanced organic synthesis.

Beyond its direct use in Fondaparinux Sodium production, this glucofuranose derivative also serves as a versatile building block in broader organic chemistry. Its protected hydroxyl groups and the chiral centers within the furanose ring offer opportunities for diverse chemical modifications, leading to the creation of novel compounds with potential applications in materials science, biochemistry, and other specialized fields. Therefore, for those involved in pharmaceutical intermediate manufacturing or general organic synthesis, understanding the sourcing and utility of 1,2-O-Isopropylidene-3-benzyloxy-D-glucofuranose is vital for advancing scientific and industrial objectives.