The advancement of modern chemistry relies heavily on the availability of versatile and precisely engineered building blocks. Among these, carbohydrate derivatives play a significant role, offering unique structural and stereochemical features. 3-O-Benzyl-1,2-O-isopropylidene-α-D-glucofuranose, identified by its CAS number 22529-61-9, is a prime example of such a critical intermediate, particularly valued in pharmaceutical synthesis and broader fine chemical applications.

The molecular structure of 3-O-Benzyl-1,2-O-isopropylidene-α-D-glucofuranose is characterized by its formula C16H22O6 and a molecular weight of 310.34. This protected form of D-glucofuranose features an isopropylidene acetal protecting the 1,2-diol and a benzyl ether protecting the 3-hydroxyl group. These protecting groups are strategically employed to control reactivity during multi-step synthesis. Physically, the compound is typically an oil, often described as clear, colorless to yellow, with properties such as a density of approximately 1.29 g/cm³. Its stability and reactivity profile make it an attractive choice for complex synthetic schemes.

The most prominent application for 3-O-Benzyl-1,2-O-isopropylidene-α-D-glucofuranose is its crucial role as an intermediate in the production of Fondaparinux Sodium. Fondaparinux is a synthetic anticoagulant that mimics the action of the most active fraction of heparin. The synthesis of such a complex oligosaccharide demands precise precursors, and this glucofuranose derivative serves as an essential starting material, providing the correct stereochemistry and functionalization required for building the active pharmaceutical ingredient. This makes it indispensable for pharmaceutical intermediate manufacturing.

For researchers and industrial clients, securing a reliable supply of 3-O-Benzyl-1,2-O-isopropylidene-α-D-glucofuranose is essential. The compound is available from various chemical suppliers globally, with many prominent manufacturers operating in China. When sourcing this chemical, key considerations include purity levels (often specified as a minimum of 97%), the available quantities ranging from laboratory-scale grams to bulk kilograms, and the overall reliability of the manufacturer. Ensuring a consistent and high-quality source is vital for the efficiency and success of synthesis projects.

Beyond its vital role in pharmaceutical synthesis, 3-O-Benzyl-1,2-O-isopropylidene-α-D-glucofuranose also serves as a valuable building block in general organic synthesis. Its protected carbohydrate framework allows for selective manipulation, enabling the creation of diverse novel molecules. Chemists can leverage its structure to explore new reactions and develop innovative compounds for various applications in fine chemicals and materials science. Therefore, for any organization involved in advanced chemical synthesis, understanding the properties and sourcing of this key intermediate is paramount.