Tolvaptan (CAS 150683-30-0) stands out in the field of medical chemistry as a potent and selective antagonist of the vasopressin V2 receptor. This specific action is central to its therapeutic efficacy in addressing conditions characterized by excessive water retention and low serum sodium levels, commonly known as hyponatremia. For healthcare professionals and researchers, understanding the intricacies of its vasopressin antagonist action is key to optimizing its clinical use.

The vasopressin V2 receptor is primarily located in the collecting ducts of the kidneys, where it mediates the action of antidiuretic hormone (ADH) to regulate water reabsorption. By selectively blocking these receptors, Tolvaptan interferes with ADH's ability to promote water retention, thereby increasing the excretion of free water. This process helps to restore normal serum sodium concentrations. This precise mechanism is what healthcare providers leverage when deciding how to treat hyponatremia with Tolvaptan, especially in cases unresponsive to other therapies.

The clinical application of Tolvaptan is carefully managed due to specific Tolvaptan safety precautions that must be observed. The potential for rapid correction of hyponatremia leading to osmotic demyelination syndrome necessitates close monitoring of serum sodium levels, particularly during the initial phases of treatment. The drug is typically initiated in a hospital setting. Furthermore, potential liver injury has been noted, underscoring the importance of limiting treatment duration and careful patient selection. These considerations highlight the need for professionals to be well-informed about the compound's profile.

For manufacturers and researchers, securing a consistent supply of high-quality Tolvaptan is crucial. Identifying a reputable Tolvaptan API supplier in China ensures access to a reliable source of this vital pharmaceutical intermediate. The specifications for Tolvaptan, including its chemical formula (C26H25ClN2O3) and physical appearance (white powder), are critical for quality control. Through diligent research and a commitment to safety, Tolvaptan continues to be a cornerstone in the management of complex fluid and electrolyte disorders.