Hyponatremia, a condition characterized by low sodium levels in the blood, can stem from various underlying health issues such as heart failure, cirrhosis, and Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Effectively managing hyponatremia is crucial to prevent serious neurological complications. In this context, Tolvaptan (CAS 150683-30-0) emerges as a significant therapeutic agent. As a selective vasopressin V2 receptor antagonist, Tolvaptan plays a pivotal role in regulating water balance within the body.

The primary mechanism of action for Tolvaptan involves blocking the effects of vasopressin in the kidneys. Vasopressin, also known as antidiuretic hormone (ADH), normally promotes water reabsorption. By antagonizing the V2 receptors, Tolvaptan inhibits this process, leading to increased excretion of free water and, consequently, a rise in serum sodium concentration. This targeted action makes it an essential tool for patients whose hyponatremia is resistant to fluid restriction or other treatments. Understanding the Tolvaptan mechanism of action is key to appreciating its therapeutic utility.

When considering how to treat hyponatremia with Tolvaptan, safety is paramount. Medical professionals emphasize that Tolvaptan should be initiated and re-initiated in a hospital setting where serum sodium levels can be closely monitored. This is due to the risk of osmotic demyelination syndrome (ODS), a serious neurological condition that can occur if serum sodium levels are corrected too rapidly. Patients with severe malnutrition, alcoholism, or advanced liver disease may require even slower rates of correction. Adhering to Tolvaptan safety precautions ensures patient well-being during treatment.

For those seeking to source this critical compound, identifying a reliable Tolvaptan API supplier in China is essential. The quality and purity of the pharmaceutical intermediate directly impact the efficacy and safety of the final drug product. Manufacturers rely on consistent supply chains to meet patient needs effectively. The chemical properties of Tolvaptan, such as its molecular formula C26H25ClN2O3 and molecular weight of 448.94, are well-documented, providing researchers and manufacturers with the necessary technical specifications. Sourcing high-quality Tolvaptan is a vital step in the drug development and manufacturing process, underscoring the importance of selecting reputable suppliers.