For scientists and chemists working at the cutting edge of drug discovery and chemical synthesis, a thorough understanding of specialized intermediates is crucial. Boc-(R)-3-Amino-4-(3,4-difluorophenyl)butyric acid (CAS: 269396-59-0) is one such compound, valued for its unique structural features and broad utility. As a leading manufacturer and supplier, we are dedicated to providing researchers with comprehensive information and high-quality materials to support their critical work.

Chemical Identity and Properties

Boc-(R)-3-Amino-4-(3,4-difluorophenyl)butyric acid is an N-protected, chiral amino acid derivative. Its molecular formula is C15H19F2NO4, and it has a molecular weight of approximately 315.31 g/mol. The compound typically presents as a white to off-white solid or powder, with a reported purity of 97% or higher by HPLC. Key structural elements contributing to its utility include:

  • The Boc Protecting Group: The tert-butyloxycarbonyl (Boc) group is attached to the amine nitrogen, serving as a protecting group that can be selectively removed under mild acidic conditions. This is fundamental for controlled synthesis in peptide chemistry and organic transformations.
  • Chirality: The designation (R) indicates a specific stereochemical configuration at the alpha-carbon (or the relevant chiral center in this derivative). Chirality is critical in pharmaceuticals as enantiomers often exhibit vastly different biological activities and safety profiles.
  • The 3,4-Difluorophenyl Moiety: The presence of two fluorine atoms on the phenyl ring significantly influences the electronic properties and lipophilicity of the molecule. This fluorination often enhances metabolic stability, alters binding affinities, and can improve the pharmacokinetic properties of the final drug product.

These properties make it an invaluable building block for creating complex molecules with tailored biological and chemical characteristics.

Key Applications in Research and Development

The versatility of Boc-(R)-3-Amino-4-(3,4-difluorophenyl)butyric acid makes it a sought-after intermediate across several scientific disciplines:

  • Peptide Synthesis: It is a critical component in the synthesis of peptides, especially those requiring specific structural modifications or enhanced stability due to the fluorinated phenyl group. Its Boc protection allows for its incorporation into peptide chains using standard solid-phase or solution-phase methodologies.
  • Pharmaceutical Intermediate: This compound serves as a key chiral building block for the synthesis of various active pharmaceutical ingredients (APIs). Its unique structural features make it suitable for incorporation into molecules targeting a wide range of diseases, particularly those where fluorine substitution is known to improve efficacy or pharmacokinetics.
  • Drug Discovery: Researchers utilize this intermediate to explore novel chemical entities and optimize lead compounds. The ability to precisely incorporate a chiral, fluorinated amino acid derivative allows for the systematic investigation of structure-activity relationships (SAR).

Procurement and Partnership

For R&D scientists and procurement managers, securing a reliable source for high-purity intermediates is paramount. We are a dedicated manufacturer and supplier of Boc-(R)-3-Amino-4-(3,4-difluorophenyl)butyric acid, ensuring consistent quality and availability. When you choose to buy from us, you gain access to a product with guaranteed high purity and reliable batch-to-batch consistency. We encourage you to inquire about our pricing and bulk order options to support your ongoing research and development projects. Partner with us to ensure you have the high-quality chemical building blocks you need for success.