The field of targeted protein degradation (TPD) has revolutionized drug discovery, offering novel strategies to combat diseases by selectively eliminating target proteins. Central to this revolution are PROTACs (Proteolysis Targeting Chimeras), which are bifunctional molecules designed to recruit cellular machinery to degrade specific proteins. For researchers aiming to develop PROTACs that target BET (Bromodomain and Extra-Terminal) proteins, JQ-1 Carboxylic Acid (CAS: 202592-23-2) is a critical chemical intermediate. This article discusses its importance and guides those looking to buy this essential compound.

Understanding JQ-1 Carboxylic Acid's Role

JQ-1 Carboxylic Acid is a modified form of the potent BET bromodomain inhibitor, (+)-JQ1. BET proteins are epigenetic regulators involved in gene transcription, making them attractive targets for therapeutic intervention, particularly in cancer and inflammatory diseases. JQ-1 Carboxylic Acid functions as the 'target ligand' or 'warhead' in PROTACs designed to target BET proteins. Its chemical structure allows it to bind effectively to BET bromodomains, and importantly, its carboxylic acid functional group serves as a reactive site for conjugation. This enables chemists to link it via a suitable linker to an E3 ubiquitin ligase ligand, creating a functional PROTAC capable of inducing targeted protein degradation.

Why Researchers Source JQ-1 Carboxylic Acid

When undertaking PROTAC development, researchers and procurement teams prioritize several factors when they decide to buy JQ-1 Carboxylic Acid (CAS: 202592-23-2):

  • Specific BET Targeting: Its proven affinity for BET bromodomains makes it ideal for designing PROTACs with specific targets.
  • Synthesis Versatility: The carboxylic acid moiety provides a convenient anchor point for chemical synthesis, streamlining the PROTAC construction process.
  • High Purity: Researchers typically seek high purity (e.g., ≥97%) to ensure the efficiency and specificity of their PROTAC constructs and minimize side reactions.
  • Supplier Reliability: Access to a dependable supplier is crucial for uninterrupted research.

NINGBO INNO PHARMCHEM CO.,LTD. is a premier manufacturer and supplier of high-quality pharmaceutical intermediates. We understand the critical need for reliable sourcing in cutting-edge research areas like TPD. Our JQ-1 Carboxylic Acid is produced to exacting standards to support your BET-targeting PROTAC development. We encourage you to contact us for pricing inquiries and to discuss how we can fulfill your requirements for this vital chemical building block.